Influence of antimicrobial agents on contamination and chlortetracycline production
Language English Country United States Media print
Document type Comparative Study, Journal Article
PubMed
414978
DOI
10.1007/bf02876590
Knihovny.cz E-resources
- MeSH
- Anti-Bacterial Agents pharmacology MeSH
- Bacteria drug effects MeSH
- Chlortetracycline biosynthesis MeSH
- Dimethylformamide pharmacology MeSH
- Species Specificity MeSH
- Phenols pharmacology MeSH
- Fermentation MeSH
- Formaldehyde pharmacology MeSH
- Culture Media * MeSH
- Aminosalicylic Acid pharmacology MeSH
- Nitrofurazone pharmacology MeSH
- Sterilization * MeSH
- Streptomyces aureofaciens metabolism MeSH
- Hot Temperature MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Chlortetracycline MeSH
- Dimethylformamide MeSH
- Phenols MeSH
- Formaldehyde MeSH
- Culture Media * MeSH
- Aminosalicylic Acid MeSH
- Nitrofurazone MeSH
The possibility of shortening the thermal sterilization time for cultivating media was demonstrated in chlortetracycline fermentation with an industrial strain of Streptomyces aureofaciens. The medium was artificially contaminated with a mixture of eight strains of G+ and G- bacteria isolated from contaminated industrial fermentors, and the following chemical agents, either alone or in combination, were added: formaldehyde, phenol. dimethylformamide, p-aminosalicylic acid and nitrofurazone. Dimethylformamide was inhibitory even at 0.08%. formaldehyde concentrations higher than 0.05%, Nitrofurazone stimulated chlortetracycline production. The best combination was 0.01% formaldehyde added before, and 2.10-3% nitrofurazone added after short sterilization at 120 degrees C.
