Influence of antimicrobial agents on contamination and chlortetracycline production
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu srovnávací studie, časopisecké články
PubMed
414978
DOI
10.1007/bf02876590
Knihovny.cz E-zdroje
- MeSH
- antibakteriální látky farmakologie MeSH
- Bacteria účinky léků MeSH
- chlortetracyklin biosyntéza MeSH
- dimethylformamid farmakologie MeSH
- druhová specificita MeSH
- fenoly farmakologie MeSH
- fermentace MeSH
- formaldehyd farmakologie MeSH
- kultivační média * MeSH
- kyselina aminosalicylová farmakologie MeSH
- nitrofurazon farmakologie MeSH
- sterilizace * MeSH
- Streptomyces aureofaciens metabolismus MeSH
- vysoká teplota MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- Názvy látek
- antibakteriální látky MeSH
- chlortetracyklin MeSH
- dimethylformamid MeSH
- fenoly MeSH
- formaldehyd MeSH
- kultivační média * MeSH
- kyselina aminosalicylová MeSH
- nitrofurazon MeSH
The possibility of shortening the thermal sterilization time for cultivating media was demonstrated in chlortetracycline fermentation with an industrial strain of Streptomyces aureofaciens. The medium was artificially contaminated with a mixture of eight strains of G+ and G- bacteria isolated from contaminated industrial fermentors, and the following chemical agents, either alone or in combination, were added: formaldehyde, phenol. dimethylformamide, p-aminosalicylic acid and nitrofurazone. Dimethylformamide was inhibitory even at 0.08%. formaldehyde concentrations higher than 0.05%, Nitrofurazone stimulated chlortetracycline production. The best combination was 0.01% formaldehyde added before, and 2.10-3% nitrofurazone added after short sterilization at 120 degrees C.
