Jestĕ k optimálnímu slození perorálního steroidního kontraceptiva
[Optimal composition of the peroral steroid contraceptive agent]
Jazyk čeština Země Česko Médium print
Typ dokumentu anglický abstrakt, časopisecké články
PubMed
862059
- Klíčová slova
- Contraception, Contraceptive Agents, Estrogen--administraction and dosage, Contraceptive Agents, Female--administraction and dosage, Contraceptive Agents, Progestin--administraction and dosage, Contraceptive Agents--administraction and dosage, Contraceptive Methods--side effects, Ethinyl Estradiol--administraction and dosage *, Family Planning, Levonorgestrel--administraction and dosage *, Mestranol--administraction and dosage *, Oral Contraceptives--side effects *,
- MeSH
- kontraceptiva orální hormonální aplikace a dávkování analýza MeSH
- kontraceptiva orální analýza MeSH
- lidé MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- Názvy látek
- kontraceptiva orální hormonální MeSH
- kontraceptiva orální MeSH
The effects of exogenous estrogens on the liver are considered to be 1 of the more difficult obstacles in working out an optimal steroid contraceptive, as the liver is 1 of the specific terminal organs for estrogens. The estrogens used in oral steroid contraceptives are ethinyl estradiol (EE) and mestranol (ME). Attempts to overcome the effects of these exogenous estrogens has lead to investigations of the possibilities of gestagens, which have a significant effect on cytoplasmatic receptors in the cells of the terminal tissues. An optimal steroid compound, which maximizes the contraceptive action while minimizing the side effects has been worked out, consisting of daily doses of .03 mg of EE and .15 mg of d-norgestrel. This compound is considered to sufficiently compensate the estrogen effects of its estrogen component through the action of the gestagen component.
