In vitro production of the factors effective in the transfer of experimental autoimmune aspermatogenesis
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
1100441
Knihovny.cz E-resources
- MeSH
- Lymphocyte Activation MeSH
- Antigens MeSH
- Autoantibodies analysis MeSH
- Cytotoxicity Tests, Immunologic MeSH
- Cell Migration Inhibition MeSH
- Macrophage Migration-Inhibitory Factors * MeSH
- Macrophages immunology MeSH
- Guinea Pigs MeSH
- Spermatogenesis * MeSH
- Spermatozoa immunology MeSH
- In Vitro Techniques MeSH
- Testis immunology MeSH
- Antibody Formation MeSH
- Animals MeSH
- Check Tag
- Guinea Pigs MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Antigens MeSH
- Autoantibodies MeSH
- Macrophage Migration-Inhibitory Factors * MeSH
We studied the biological effects of the factors released into the culture medium by the lymphocytes from animals sensitized with testicular antigen. The supernatants from cultures of these lymphocytes were active in vitro in the migration inhibition tests because they transferred the sensitivity to normal spleen cells. In vivo, they transferred aspermatogenesis in the allogeneic and xenogeneic system. The results suggest a specific effect on the behaviour of macrophages rather than a direct cytotoxic effect of the active factors.
