Ramihyphin A at subfungistatic concentrations stimulates ramification of hyphae of filamentous fungi. Stimulation of terminal ramification of hyphae that can be observed particularly in phytopathogenic fungi is most frequent. Hyphae of Microsporon canis, Trichophyton mentagrophytes, Blastomyces dermatitidis, Coccidioides immitis and Histoplasma capsulatum ramify intensively laterally. Stimulation of the lateral ramification was observed in Monilia fructigena, Penicillium marneffei and Penicillium chrysogenum. The antibiotic induces also formation of vesicular structures in phytopathogens. Due to the substantial ramification of hyphae, both terminal and lateral, the growth of colonies is interrupted. The addition of the antibiotic to a growing colony of Botrytis cinerea induces dichotomic ramification of terminal hyphae after 3 h of growth. Lateral hyphae begin to grow later and further ramify dichotomically. Dense bundles of ramified hyphae are formed after 24 h due to the unbalanced ramification and the colony no longer increases its size.

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Biological effects of the antibiotic brefeldin A (decumbin, cyanein, ascotoxin, synergisidin): a retrospective

Identity of the antibiotic ramihyphin A and cyclosporin A

The use of antibiotics for studies of morphogenesis and differentiation in microorganisms

Effects of cyanein and ramihyphin A on the dimorphism of Paracoccidioides brasiliensis

Antibiotic-induced changes of mycelial growth of Botrytis cinerea

Colonial growth and ramihyphin A-induced changes in cell walls of Neurospora sitophila

Effects of antibiotics on the life cycle of Neurospora crassa