Some antibiotics and synthetic inhibitors affect, in several ways, the life cycle of Neurospora crassa (germination of conidia leads to myceliar growth leads to formation of conidia). Bikaverin, cyanein, scopathricin and phenethyl alcohol retard the germination of conidia, without inhibiting it completely. 5-Fluorouracil, ramihyphin A and zygosporin A (cytochalasin D) do not inhibit the germination. Bikaverin brings about a thickening of the hyphae of growing mycelium. Ramihyphin A, cyanein, scopathricin and zygosporin A stimulate the ramification of hyphae while 5-fluorouracil and phenethyl alcohol do not affect the myceliar morphology apart from their inhibitory effect on growth. Actinomycin D, 5-fluorouracil, cycloheximide, ramihyphin A and partially also sodium iodoacetate inhibit to a different degree the photoinduced formation of conidia. The inhibition by 5-fluorouracil is very conspicuous when the agent is present during the photoinduction but considerably weaker when it is applied 2 h after the photoinduction.

See more in PubMed

Experientia. 1969 Sep 15;25(9):984-5 PubMed

J Bacteriol. 1972 Mar;109(3):1097-100 PubMed

J Bacteriol. 1964 Dec;88:1580-4 PubMed

Folia Microbiol (Praha). 1975;20(2):97-102 PubMed

Z Allg Mikrobiol. 1973;13(4):287-98 PubMed

Science. 1966 Feb 11;151(3711):696-8 PubMed

J Bacteriol. 1965 Oct;90(4):1073-81 PubMed

Folia Microbiol (Praha). 1974;19(6):507-11 PubMed

J Bacteriol. 1972 Jan;109(1):162-8 PubMed

Mol Gen Genet. 1970;109(2):142-51 PubMed

Science. 1969 Jan 10;163(3863):192-4 PubMed

Arch Mikrobiol. 1965 May 28;51:1-8 PubMed

J Chem Soc Perkin 1. 1971;16:2786-8 PubMed

Dev Biol. 1967 Jun;15(6):575-98 PubMed

Biological effects of the antibiotic brefeldin A (decumbin, cyanein, ascotoxin, synergisidin): a retrospective

The use of antibiotics for studies of morphogenesis and differentiation in microorganisms

Suppression of photo-induced sporulation in Trichoderma viride by inhibitors

Antibiotic-induced changes of mycelial growth of Botrytis cinerea

Colonial growth and ramihyphin A-induced changes in cell walls of Neurospora sitophila