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Changes in chromatin structure due to hypomethylation induced with 5-azacytidine or DL-ethionine

. 1992 Dec 07 ; 314 (1) : 13-6.

Language English Country England, Great Britain Media print

Document type Journal Article

Changes in chromatin structure of the HRS60 family of repetitive sequences in tobacco DNA were studied after hypomethylation induced with 5-azacytidine or DL-ethionine. The TaqI site in the HRS60 units lies in nucleosomal core regions and its cleavage is enhanced in the hypomethylated chromatin. In contrast, the cleavage of the Sau3AI site located in linker DNA does not depend on the level of methylation of DNA.

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