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PubMed

Záznam pochází z PubMed

Telomeres in evolution and evolution of telomeres

Fajkus, Jirí
Autor Fajkus, Jirí Laboratory of Functional Genomics and Proteomics, Faculty of Science, Masaryk University Brno, Královopolská 135, CZ-61265 Brno, Czech Republic. fajkus@ibp.cz
Sýkorová, Eva
Autor Sýkorová, Eva
Leitch, Andrew R
Autor Leitch, Andrew R

Chromosome research. 2005 ; 13 (5) : 469-79.

Chromosome Res
ISSN 0967-3849
Zdroj

Jazyk angličtina Země Nizozemsko Médium print

Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem, přehledy

Perzistentní odkaz https://www.medvik.cz/link/pmid16132812

PubMed 16132812
DOI 10.1007/s10577-005-0997-2
Knihovny.cz E-zdroje

MeSH
chromozomy rostlin genetika metabolismus MeSH
fylogeneze MeSH
genom rostlinný * MeSH
minisatelitní repetice MeSH
molekulární evoluce * MeSH
proteiny vázající telomery fyziologie MeSH
repetitivní sekvence nukleových kyselin MeSH
retroelementy MeSH
telomery genetika fyziologie MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH
přehledy MeSH
srovnávací studie MeSH
Názvy látek
proteiny vázající telomery MeSH
retroelementy MeSH

This paper examines telomeres from an evolutionary perspective. In the monocot plant order Asparagales two evolutionary switch-points in telomere sequence are known. The first occurred when the Arabidopsis-type telomere was replaced by a telomere based on a repeat motif more typical of vertebrates. The replacement is associated with telomerase activity, but the telomerase has low fidelity and this may have implications for the binding of telomeric proteins. At the second evolutionary switch-point, the telomere and its mode of synthesis are replaced by an unknown mechanism. Elsewhere in plants (Sessia, Vestia, Cestrum) and in arthropods, the telomere "typical" of the group is lost. Probably many other groups with "unusual" telomeres will be found. We question whether telomerase is indeed the original end-maintenance system and point to other candidate processes involving t-loops, t-circles, rolling circle replication and recombination. Possible evolutionary outcomes arising from the loss of telomerase activity in alternative lengthening of telomere (ALT) systems are discussed. We propose that elongation of minisatellite repeats using recombination/replication processes initially substitutes for the loss of telomerase function. Then in more established ALT groups, subtelomeric satellite repeats may replace the telomeric minisatellite repeat whilst maintaining the recombination/replication mechanisms for telomere elongation. Thereafter a retrotransposition-based end-maintenance system may become established. The influence of changing sequence motifs on the properties of the telomere cap is discussed. The DNA and protein components of telomeres should be regarded--as with any other chromosome elements--as evolving and co-evolving over time and responding to changes in the genome and to environmental stresses. We describe how telomere dysfunction, resulting in end-to-end chromosome fusions, can have a profound effect on chromosome evolution and perhaps even speciation.

Laboratory of Functional Genomics and Proteomics Faculty of Science Masaryk University Brno Královopolská 135 CZ 61265 Brno Czech Republic

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