Evidence for a sequence-directed conformation periodicity in the genomic highly repetitive DNA detectable with single-strand-specific chemical probe potassium permanganate
Jazyk angličtina Země Nizozemsko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
8871822
DOI
10.1007/bf02257269
Knihovny.cz E-zdroje
- MeSH
- Brassica genetika MeSH
- distamyciny MeSH
- DNA primery genetika MeSH
- DNA rostlinná chemie genetika MeSH
- jedovaté rostliny MeSH
- konformace nukleové kyseliny * MeSH
- manganistan draselný MeSH
- mapování chromozomů MeSH
- molekulární sekvence - údaje MeSH
- molekulární sondy MeSH
- polymorfismus genetický MeSH
- repetitivní sekvence nukleových kyselin * MeSH
- sekvence nukleotidů MeSH
- tabák genetika MeSH
- vazebná místa MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- distamyciny MeSH
- DNA primery MeSH
- DNA rostlinná MeSH
- manganistan draselný MeSH
- molekulární sondy MeSH
- stallimycin MeSH Prohlížeč
A single-strand-specific chemical probe, potassium permanganate (KMnO4), was used to study the sequence-dependent conformation periodicity of tandem multicopy repetitive DNA sequences HRS60 and GRS (Nicotiana Species) at the level of single base pair and dinucleotide step. Local DNA structures, sensitive to KMnO4, revealed periodicity of 182 +/- 2 bp, equal to the length of repeat units. Permanganate-sensitive local structures were mapped to both DNA strands of genomic HRS60 sequences and were found to be linked to d(A)n tracts. These adenine tracts are located in the proximity of the intrinsically curved domains. Distamycin A increased reactivity of the DNA but decreased the specificity of DNA cleavage. Similar conformation periodicity has been detected also in the 'canrep' family of repeats (Brassica species). All studied repetitive sequences are predominantly located in the constitutive heterochromatin. We discuss the role of conformation periodicities in relation to a structural code for nucleosome phasing at tandem arrays of DNA repeats.
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GENBANK
X07519, X12489, X12490, X12491, X15068, X78263, X78264, X78265, X78266, X78267, X78268
