Nĕkteré problémy vývoje vakcín zalozených na rekombinantním viru vakcínie
[Problems associated with the development of vaccines based on recombinant vaccinia virus]
Language Czech Country Czech Republic Media print
Document type English Abstract, Journal Article
PubMed
1288884
- MeSH
- Genetic Vectors MeSH
- Mice MeSH
- Vaccines, Synthetic * immunology MeSH
- Hepatitis B Vaccines immunology MeSH
- Vaccinia virus * MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Names of Substances
- Vaccines, Synthetic * MeSH
- Hepatitis B Vaccines MeSH
A collection of single and double vaccinia virus recombinants was prepared. The recombinants contained either genes for different forms of surface protein or core protein of HBV or the gene for glycoprotein I of varicella-zoster virus. Cells infected with the recombinants produced the respective foreign antigens. Specific antibodies against the heterologous antigens were induced in mice immunized with the recombinants. The insertion of the second foreign gene into the genome of single recombinants did not influence either the extent of production of the first protein in vitro or its immunogenicity for mice.
