Beta--CCE and FG 7142 increase defensiveness during intraspecies encounters in mice
Language English Country Germany Media print
Document type Journal Article
PubMed
1329133
DOI
10.1007/bf02245308
Knihovny.cz E-resources
- MeSH
- Aggression drug effects MeSH
- GABA-A Receptor Antagonists * MeSH
- Interpersonal Relations MeSH
- Carbolines pharmacology MeSH
- Mice, Inbred ICR MeSH
- Mice MeSH
- Motor Activity drug effects MeSH
- Escape Reaction drug effects MeSH
- Anxiety chemically induced MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- GABA-A Receptor Antagonists * MeSH
- beta-carboline-3-carboxylic acid ethyl ester MeSH Browser
- FG 7142 MeSH Browser
- Carbolines MeSH
The effects were ascertained of two partial inverse agonists at benzodiazepine receptors (beta-CCE and FG 7142) on the incidence of timid (defensive-escape), aggressive, sociable and locomotor activities in both timid and aggressive singly-housed male mice, treated with drugs in paired interactions with untreated non-aggressive males. FG 7142 (5 mg/kg) and beta-CCE (8 mg/kg) increased defenses and escapes without producing other behavioral changes in timid mice. FG 7142 (20 mg/kg) and beta-CCE (1-8 mg/kg) moderately increased defenses and alert postures in aggressive mice and this effect was associated with marked reduction of aggressive behavior. FG 7142 (20 and 80 mg/kg) also decreased walking across cage in aggressive mice. It is concluded that beta-CCE and FG 7142 produced behavioral changes which could be interpreted as "anxiogenic".
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