Beta--CCE and FG 7142 increase defensiveness during intraspecies encounters in mice
Jazyk angličtina Země Německo Médium print
Typ dokumentu časopisecké články
PubMed
1329133
DOI
10.1007/bf02245308
Knihovny.cz E-zdroje
- MeSH
- agrese účinky léků MeSH
- antagonisté receptorů GABA-A * MeSH
- interpersonální vztahy MeSH
- karboliny farmakologie MeSH
- myši inbrední ICR MeSH
- myši MeSH
- pohybová aktivita účinky léků MeSH
- úniková reakce účinky léků MeSH
- úzkost chemicky indukované MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antagonisté receptorů GABA-A * MeSH
- beta-carboline-3-carboxylic acid ethyl ester MeSH Prohlížeč
- FG 7142 MeSH Prohlížeč
- karboliny MeSH
The effects were ascertained of two partial inverse agonists at benzodiazepine receptors (beta-CCE and FG 7142) on the incidence of timid (defensive-escape), aggressive, sociable and locomotor activities in both timid and aggressive singly-housed male mice, treated with drugs in paired interactions with untreated non-aggressive males. FG 7142 (5 mg/kg) and beta-CCE (8 mg/kg) increased defenses and escapes without producing other behavioral changes in timid mice. FG 7142 (20 mg/kg) and beta-CCE (1-8 mg/kg) moderately increased defenses and alert postures in aggressive mice and this effect was associated with marked reduction of aggressive behavior. FG 7142 (20 and 80 mg/kg) also decreased walking across cage in aggressive mice. It is concluded that beta-CCE and FG 7142 produced behavioral changes which could be interpreted as "anxiogenic".
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