The increase in cAMP and cGMP levels in the oestrogenized rat hypophysis
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
1337470
Knihovny.cz E-resources
- MeSH
- Cyclic AMP biosynthesis MeSH
- Estradiol pharmacology MeSH
- Cyclic GMP biosynthesis MeSH
- Hypertrophy chemically induced MeSH
- Pituitary Gland drug effects metabolism pathology MeSH
- Rats MeSH
- Nitroprusside pharmacology MeSH
- Rats, Wistar MeSH
- Prolactin blood MeSH
- Organ Size MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Cyclic AMP MeSH
- Estradiol MeSH
- Cyclic GMP MeSH
- Nitroprusside MeSH
- Prolactin MeSH
Male and female rats were given oestradiol benzoate (1 mg s.c. twice a week for 3 weeks) and/or sodium nitroprusside (SN), a donor of nitric oxide (NO), which was administered in their food in amounts of 0.2 or 0.6 mg/rat/day. Neither oestradiol-induced hypertrophy of the hypophysis, nor the serum prolactin (PRL) level, was affected by the simultaneous administration of SN. The PRL content of the hypophysis rose after oestradiol in the males, but the increase was again uninfluenced by the simultaneous administration of SN and the cAMP content of the hypophysis--raised after oestradiol--was likewise unaffected. The amount of cGMP in the hypophysis after oestradiol rose only in males. Both the serum and the hypophyseal prolactin level were found to be correlated to the cAMP and the cGMP content of the hypophysis. It was found that the simultaneous administration of SN together with oestradiol slightly reduced the increase in the cGMP content of the hypophysis elicited with oestradiol treatment only.
In vivo antiestrogenic activity of mifepristone in the rat
