Differences in proinflammatory activity of several immunomodulatory derivatives of muramyl dipeptide (MDP) with special reference to the mechanism of the MDP effects
Jazyk angličtina Země Švýcarsko Médium print
Typ dokumentu časopisecké články
PubMed
1414682
DOI
10.1007/bf01991241
Knihovny.cz E-zdroje
- MeSH
- acetylmuramyl-alanyl-isoglutamin * analogy a deriváty chemie farmakologie MeSH
- adjuvancia imunologická farmakologie MeSH
- edém chemicky indukované patologie MeSH
- inbrední kmeny potkanů MeSH
- indomethacin farmakologie MeSH
- králíci MeSH
- krysa rodu Rattus MeSH
- makrofágy účinky léků MeSH
- noha (od hlezna dolů) patologie MeSH
- vztahy mezi strukturou a aktivitou MeSH
- zánět chemicky indukované patologie MeSH
- zvířata MeSH
- Check Tag
- králíci MeSH
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- acetylmuramyl-alanyl-isoglutamin * MeSH
- adjuvancia imunologická MeSH
- indomethacin MeSH
Immunomodulatory agents, muramyl dipeptide (MDP) and several of its analogues, i.e. adamantylamide dipeptide, murametide, murabutide and their glucosaminylated derivatives, were tested for edemagenic activity in rats. Given systemically in aqueous solutions, only MDP and glucosaminylated MDP, at the dose of 3 mg/kg (s.c. or p.o.), were found to produce edematous swelling of the paws. Local (intra-pad) application of MDP was more effective than the systemic one. Supernatants of macrophages, in vitro cultured in presence of MDP, caused the swelling as well. The edema was of a transient nature. After reaching the maximum severity (about 6 h after injection of MDP solution or 1 h after macrophage supernatants), it was subsiding and disappeared completely within approximately 6 days after cessation of the treatment. It was found that this type of rat paw edema is probably a prostaglandin-dependent consequence of macrophage activation. Hypotheses on the involvement of immunoregulatory cytokines, and possible chemical structure-inflammatory activity relationships have been suggested.
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