Joint disease, ankylosing enthesopathy (ANKENT) of the ankle, occurs naturally in mice. ANKENT depends on the genetical constitution, sex, and age, and its frequency varies among inbred strains of normal mice. We found the highest frequency of ANKENT in B10.BR (H-2k) males. The H-2k haplotype appears to be a relative risk factor, which increases the susceptibility to ANKENT. The aetiology of ANKENT is unknown but an involvement of microbial agents in the environment is supposed.

Institute of Molecular Genetics Czechoslovak Academy of Sciences Praha

Lipopolysaccharide treatment suppresses spontaneously developing ankylosing enthesopathy in B10.BR male mice: the potential role of interleukin-10

Sexual dimorphism, but not testosterone itself, is responsible for ankylosing enthesitis of the ankle in B10.BR (H-2k) male mice

Experimental colitis does not increase the prevalence of ANKENT, a spontaneous joint disease in mice