Experimental colitis does not increase the prevalence of ANKENT, a spontaneous joint disease in mice
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
15881413
DOI
10.1007/bf02931559
Knihovny.cz E-resources
- MeSH
- Ankylosis epidemiology etiology MeSH
- Foot Joints pathology MeSH
- Colon pathology MeSH
- Humans MeSH
- Disease Models, Animal MeSH
- Mice, Inbred C57BL MeSH
- Mice MeSH
- Prevalence MeSH
- Dextran Sulfate adverse effects MeSH
- Colitis, Ulcerative chemically induced complications pathology physiopathology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Dextran Sulfate MeSH
A possible relationship between intestinal inflammation and joint disease development was investigated. Clinical symptoms of colitis--diarrhea and rectal bleeding--were confirmed by findings of inflammatory processes in the colon in dextran sodium sulfate-treated mice and joint ankylosing enthesopathy (ANKENT) developed in 12.8 % mice with chronic colitis and 13.6 % mice in the control group. Consequently no significant difference in ANKENT frequency was found between mice with and without chronic colitis and the occurrence of ANKENT in both groups was typical for conventional conditions. ANKENT cannot be triggered solely a generalized inflammatory process in the gut.
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