Non-enzymatic glycosylation of myosin: effects of diabetes and ageing
Jazyk angličtina Země Slovensko Médium print
Typ dokumentu časopisecké články
PubMed
1426977
Knihovny.cz E-zdroje
- MeSH
- Ca2+-ATPasy metabolismus MeSH
- diabetes mellitus metabolismus MeSH
- experimentální diabetes mellitus metabolismus MeSH
- glykosylace MeSH
- krysa rodu Rattus MeSH
- lidé MeSH
- myokard metabolismus MeSH
- myosiny analýza metabolismus MeSH
- senioři MeSH
- srdce růst a vývoj MeSH
- stárnutí metabolismus MeSH
- svaly metabolismus MeSH
- vývoj svalů MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- lidé MeSH
- senioři MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- Ca2+-ATPasy MeSH
- myosiny MeSH
The influence of diabetes mellitus, streptozotocin-induced diabetes and ageing on the non-enzymatic glycosylation of myosin from cardiac and skeletal muscles was investigated. In cardiac muscle, and to a lesser extent also in skeletal muscles of the rat, non-enzymatic glycosylation of myosin increases with the age, as measured in 6-, 12- and 29-month-old animals. Skeletal muscle myosin from diabetic humans and also that from diabetic rat cardiac muscle are more glycosylated when compared with control myosin preparations. Ca(2+)-ATPase activity of myosin is lower in muscles of diabetic individuals as compared with control muscles.
