Osteoblastic and chondroblastic response to a variety of locally administered immunomodulators in mice
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
1478324
Knihovny.cz E-resources
- MeSH
- Adjuvants, Immunologic pharmacology MeSH
- Cartilage cytology drug effects MeSH
- Mice, Inbred Strains MeSH
- Bone and Bones drug effects physiology MeSH
- Mice MeSH
- Osteoblasts drug effects MeSH
- Osteogenesis drug effects physiology MeSH
- Bone Resorption MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Adjuvants, Immunologic MeSH
Administration into mouse shank muscles of various immunomodulators which directly or indirectly activate lymphocytes (BCG, Con A, Carrageenan IV, Dextran, PHA-M, PWM, lipopolysaccharides from Corynebacterium) have a dual effect on local bones, stimulating both periosteal bone formation and bone resorption, the former being dominant. These effects vary in frequency and magnitude, the most potent stimulation of periosteal bone formation being observed after administration of Con A and BCG in complete Freund adjuvant. BCG was also a strong inducer of bone resorption in vivo. Concanavalin A and, to a lesser degree, other immunomodulators applied, when administered subcutaneously into the pinna, also have induced perichondrial chondrogenesis. These novel effects of immunodulators could be applied in the field of skeletal tissues regeneration.
