Bacterial infection modulated by glucan: a search for the host defense potentiation mechanisms
Language English Country United States Media print
Document type Journal Article
PubMed
1505872
DOI
10.1007/bf02836620
Knihovny.cz E-resources
- MeSH
- Phagocytosis MeSH
- Fluorescent Antibody Technique MeSH
- Glucans metabolism MeSH
- Klebsiella Infections immunology microbiology mortality MeSH
- Kinetics MeSH
- Klebsiella pneumoniae growth & development MeSH
- Mice, Inbred ICR MeSH
- Mice MeSH
- Lung microbiology MeSH
- Spleen microbiology MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Glucans MeSH
Interactions between bacteria and the host were studied from day 0 up to day 10 post-challenge in mice pretreated with soluble glucan (20 mg/kg i.p.) and challenged supralaryngeally with a virulent strain of Klebsiella pneumoniae. In the initial phase of infection, clearance of bacteria in the airways of glucan-treated mice was improved to an extent comparable with the vaccinated group but, in contrast to the immunized animals, subsequent regrowth of the bacterial inoculum was not prevented. The efficacy of defense, based during the entire course of infection mainly upon phagocytosis by neutrophils, markedly increased at intervals corresponding to the onset of humoral immune response. No evidence was obtained to indicate an enhanced involvement of alveolar macrophages in the phagocytosis of bacteria in glucan-stimulated mice. The results further support the notion that improvement of specific immune responsiveness rather than activation of nonspecific effector functions might be the most important expression of the host-defense-potentiating capacity of glucan and related stimulants of microbial origin.
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