In vitro activity of antifungal agents against clinical isolates of aspergilli
Jazyk angličtina Země Německo Médium print
Typ dokumentu srovnávací studie, časopisecké články
PubMed
1520959
Knihovny.cz E-zdroje
- MeSH
- antibiotická rezistence MeSH
- antifungální látky farmakologie MeSH
- Aspergillus účinky léků růst a vývoj izolace a purifikace MeSH
- druhová specificita MeSH
- inhibitory růstu farmakologie MeSH
- lidé MeSH
- mikrobiální testy citlivosti MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- Názvy látek
- antifungální látky MeSH
- inhibitory růstu MeSH
The growth-inhibitory effect of 9 antifungal agents against 32 strains of aspergilli belonging to 10 species was studied. MIC values were determined in a microtiter dilution method using Brain Heart Infusion Broth (polyenes, azoles) and a medium with Yeast Nitrogen Base (5-flucytosine). Saperconazole was the most active agent against all isolates tested, the growth of 90% being inhibited at a concentration of 0.09 mg l-1. The susceptibility profile of individual species differed only little, with the exception of high MIC values of polyenes in A. terreus. Nine isolates (28%) were resistant to 5-flucytosine. The intra-species variation of susceptibility studied in A. fumigatus was only little pronounced.
Institute of Experimental Biopharmacy Czechoslovak Academy of Sciences Hradec Králové Czechoslovakia
Occurrence of itraconazole-tolerant micromycetes in the soil and food products
