The EHA Research Roadmap: Malignant Lymphoid Diseases
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Document type Journal Article
Grant support
P30 CA008748
NCI NIH HHS - United States
PubMed
35620592
PubMed Central
PMC9126526
DOI
10.1097/hs9.0000000000000726
Knihovny.cz E-resources
- Publication type
- Journal Article MeSH
Aix Marseille Univ CNRS INSERM CIML Marseille France
Amsterdam UMC Vrije Universiteit Amsterdam Cancer Center Amsterdam the Netherlands
Barts Cancer Institute Queen Mary University of London United Kingdom
Berlin Institute of Health Berlin Germany
Biotech Research and Innovation Centre University of Copenhagen Denmark
Centre for Haemato Oncology Barts Cancer Institute Queen Mary University of London United Kingdom
Città di Lecce Hospital GVM Care and Research Lecce Italy
Clinical and Transplant Unit University Hospital of Salamanca Spain
Comprehensive Cancer Center Ulm Sektion CLL Klinik für Innere Medizin 3 Universität Ulm Germany
Département de Pathologie Hôpital Henri Mondor AP HP Créteil France
Department of Hematology Hospital Clínic de Barcelona Spain
Department of Hematology Niguarda Hospital Milano Italy
Department of Hematology Rigshospitalet Copenhagen Denmark
Department of Internal Medicine 2 Haematology and Oncology DIAKO Hospital Bremen Germany
Department of Medicine 1 Division of Oncology Medical University of Vienna Austria
Department of Medicine 3 LMU Hospital Munich Germany
Department of Medicine at the University of Salamanca Spain
Division of Medical Oncology and Immune related Tumors National Cancer Institute Aviano Italy
El Instituto de Investigación Biomédica de Salamanca Salamanca Spain
Hematology and Medical Oncology University Medicine Goettingen Germany
Hematology Department University Hospital Hotel Dieu Nantes France
Hospital de la Santa Creu 1 Sant Pau Autonomous University of Barcelona Spain
Immunology and Cell Therapy Lab at Rennes University Hospital Rennes France
INSERM U1245 Department of Hematology Centre Henri Becquerel and Université de Rouen France
Institut d'Investigacions Biomèdiques August Pi i Sunyer Barcelona Spain
Institute of Applied Biosciences Centre for Research and Technology Hellas Thessaloniki Greece
Institute of Experimental Cancer Research CCC Ulm University Hospital Ulm Germany
Lymphoma Unit Department of Onco hematology IRCCS San Raffaele Scientific Institute Milano Italy
Medical Department A for Hematology Oncology and Pneumology University Hospital Münster Germany
Medical University of Lodz Poland
Pediatric Hematology Oncology Sorbonne Université APHP hôpital A Trousseau Paris France
School of Medicine University of Nottingham United Kingdom
Service d'Hématologie Clinique du Centre Hospitalier Universitaire de Nantes France
Service Hematologie Clinique Therapie Cellulaire CHU Amiens Picardie Amiens France
Skåne University and Lund University Lund Sweden
St James's Institute of Oncology Leeds United Kingdom
Università Vita Salute San Raffaele and IRCCS Ospedale San Raffaele Milano Italy
Université Catholique de Louvain CHU UcL Namur Yvoir Belgium
University Hospital Centre Zagreb and Medical School University of Zagreb Croatia
University of Helsinki and Helsinki University Hospital Comprehensive Cancer Centre Helsinki Finland
See more in PubMed
Engert A, Balduini C, Brand A, et al. . The European Hematology Association Roadmap for European Hematology Research: a consensus document. Haematologica. 2016;101:115–208. PubMed PMC
Sant M, Allemani C, Tereanu C, et al. . Incidence of hematologic malignancies in Europe by morphologic subtype: results of the HAEMACARE project. Blood. 2010;116:3724–3734. PubMed
Marcos-Gragera R, Allemani C, Tereanu C, et al. . Survival of European patients diagnosed with lymphoid neoplasms in 2000-2002: results of the HAEMACARE project. Haematologica. 2011;96:720–728. PubMed PMC
Testoni M, Zucca E, Young KH, et al. . Genetic lesions in diffuse large B-cell lymphomas. Ann Oncol. 2015;26:1069–1080. PubMed PMC
Pileri SA, Piccaluga PP. New molecular insights into peripheral T cell lymphomas. J Clin Invest. 2012;122:3448–3455. PubMed PMC
Puente XS, Pinyol M, Quesada V, et al. . Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature. 2011;475:101–105. PubMed PMC
US National Cancer Institute. International Lymphoma Epidemiology Consortium (InterLymph). 2021. https://epi.grants.cancer.gov/interlymph/. Accessed April 19, 2022. PubMed PMC
Beà S, Valdés-Mas R, Navarro A, et al. . Landscape of somatic mutations and clonal evolution in mantle cell lymphoma. Proc Natl Acad Sci U S A. 2013;110:18250–18255. PubMed PMC
Lemonnier F, Couronné L, Parrens M, et al. . Recurrent TET2 mutations in peripheral T-cell lymphomas correlate with TFH-like features and adverse clinical parameters. Blood. 2012;120:1466–1469. PubMed
Scott DW, Gascoyne RD. The tumour microenvironment in B cell lymphomas. Nat Rev Cancer. 2014;14:517–534. PubMed
Chubb D, Weinhold N, Broderick P, et al. . Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk. Nat Genet. 2013;45:1221–1225. PubMed PMC
Cerhan JR, Berndt SI, Vijai J, et al. . Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma. Nat Genet. 2014;46:1233–1238. PubMed PMC
Sant M, Minicozzi P, Mounier M, et al. . Survival for haematological malignancies in Europe between 1997 and 2008 by region and age: results of EUROCARE-5, a population-based study. Lancet Oncol. 2014;15:931–942. PubMed
Hanly P, Soerjomataram I, Sharp L. Measuring the societal burden of cancer: the cost of lost productivity due to premature cancer-related mortality in Europe. Int J Cancer. 2015;136:E136–E145. PubMed
Oerlemans S, Mols F, Nijziel MR, et al. . The impact of treatment, socio-demographic and clinical characteristics on health-related quality of life among Hodgkin’s and non-Hodgkin’s lymphoma survivors: a systematic review. Ann Hematol. 2011;90:993–1004. PubMed PMC
Gallamini A, Hutchings M, Rigacci L, et al. . Early interim 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography is prognostically superior to international prognostic score in advanced-stage Hodgkin’s lymphoma: a report from a joint Italian-Danish study. J Clin Oncol. 2007;25:3746–3752. PubMed
Radford J, Illidge T, Counsell N, et al. . Results of a trial of PET-directed therapy for early-stage Hodgkin’s lymphoma. N Engl J Med. 2015;372:1598–1607. PubMed
André MPE, Girinsky T, Federico M, et al. . Early positron emission tomography response-adapted treatment in stage I and II Hodgkin lymphoma: final results of the randomized EORTC/LYSA/FIL H10 trial. J Clin Oncol. 2017;35:1786–1794. PubMed
Fuchs M, Goergen H, Kobe C, et al. . Positron emission tomography-guided treatment in early-stage favorable Hodgkin lymphoma: final results of the International, randomized phase III HD16 trial by the German Hodgkin study Group. J Clin Oncol. 2019;37:2835–2845. PubMed
Borchmann P, Plütschow A, Kobe C, et al. . PET-guided omission of radiotherapy in early-stage unfavourable Hodgkin lymphoma (GHSG HD17): a multicentre, open-label, randomised, phase 3 trial. Lancet Oncol. 2021;22:223–234. PubMed
Johnson P, Federico M, Kirkwood A, et al. . Adapted Treatment Guided by Interim PET-CT Scan in Advanced Hodgkin’s Lymphoma. N Engl J Med. 2016;374:2419–2429. PubMed PMC
Casasnovas RO, Bouabdallah R, Brice P, et al. . PET-guided, BEACOPPescalated therapy in advanced Hodgkin lymphoma—Authors’ reply. Lancet Oncol. 2019;20:e190. PubMed
Borchmann P, Haverkamp H, Lohri A, et al. . Progression-free survival of early interim PET-positive patients with advanced stage Hodgkin’s lymphoma treated with BEACOPPescalated alone or in combination with rituximab (HD18): an open-label, international, randomised phase 3 study by the German Hodgkin Study Group. Lancet Oncol. 2017;18:454–463. PubMed
Mauz-Körholz C, Landman-Parker J, Balwierz W, et al. . Response-adapted omission of radiotherapy and comparison of consolidation chemotherapy in children and adolescents with intermediate-stage and advanced-stage classical Hodgkin lymphoma (EuroNet-PHL-C1): a titration study with an open-label, embedded, multinational, non-inferiority, randomised controlled trial. Lancet Oncol. 2022;23:125–137. PubMed PMC
Bröckelmann PJ, Goergen H, Keller U, et al. . Efficacy of Nivolumab and AVD in early-stage unfavorable classic Hodgkin lymphoma: the randomized phase 2 German Hodgkin study group NIVAHL trial. JAMA Oncol. 2020;6:872–880. PubMed PMC
Fornecker L-M, Lazarovici J, Aurer I, et al. . PET-based response after 2 cycles of brentuximab vedotin in combination with AVD for first-line treatment of unfavorable early-stage Hodgkin lymphoma: first analysis of the primary endpoint of BREACH, a randomized phase 2 trial of LYSA-FIL-EORTC Intergroup. Blood. 2017;130(suppl 1):Abstract 736.
Schmiegelow K, Attarbaschi A, Barzilai S, et al. . Consensus definitions of 14 severe acute toxic effects for childhood lymphoblastic leukaemia treatment: a Delphi consensus. Lancet Oncol. 2016;17:e231–e239. PubMed
Buchmann S, Schrappe M, Baruchel A, et al. . Remission, treatment failure, and relapse in pediatric ALL: an international consensus of the Ponte-di-Legno Consortium. Blood. 2022;139:1785–1793. PubMed PMC
Locatelli F, Zugmaier G, Rizzari C, et al. . Effect of Blinatumomab vs Chemotherapy on event-free survival among children with high-risk first-relapse B-cell acute lymphoblastic leukemia: a randomized clinical trial. JAMA. 2021;325:843–854. PubMed PMC
Gökbuget N, Dombret H, Bonifacio M, et al. . Blinatumomab for minimal residual disease in adults with B-cell precursor acute lymphoblastic leukemia. Blood. 2018;131:1522–1531. PubMed PMC
den Boer ML, Cario G, Moorman AV, et al. . Outcomes of paediatric patients with B-cell acute lymphocytic leukaemia with ABL-class fusion in the pre-tyrosine-kinase inhibitor era: a multicentre, retrospective, cohort study. Lancet Haematol. 2021;8:e55–e66. PubMed PMC
Peters C, Dalle JH, Locatelli F, et al. . Total body irradiation or chemotherapy conditioning in childhood ALL: a multinational, randomized, noninferiority phase III study. J Clin Oncol. 2021;39:295–307. PubMed PMC
Frismantas V, Dobay MP, Rinaldi A, et al. . Ex vivo drug response profiling detects recurrent sensitivity patterns in drug-resistant acute lymphoblastic leukemia. Blood. 2017;129:e26–e37. PubMed PMC
Touzart A, Mayakonda A, Smith C, et al. . Epigenetic analysis of patients with T-ALL identifies poor outcomes and a hypomethylating agent-responsive subgroup. Sci Transl Med. 2021;13:eabc4834. PubMed
Enshaei A, O’Connor D, Bartram J, et al. . A validated novel continuous prognostic index to deliver stratified medicine in pediatric acute lymphoblastic leukemia. Blood. 2020;135:1438–1446. PubMed
Kuhlen M, Kunstreich M, Gökbuget N. Osteonecrosis in adults with acute lymphoblastic leukemia: an unmet clinical need. Hemasphere. 2021;5:e544. PubMed PMC
Gökbuget N, Dombret H, Ribera JM, et al. . International reference analysis of outcomes in adults with B-precursor Ph-negative relapsed/refractory acute lymphoblastic leukemia. Haematologica. 2016;101:1524–1533. PubMed PMC
Gökbuget N, Dombret H, Giebel S, et al. . Minimal residual disease level predicts outcome in adults with Ph-negative B-precursor acute lymphoblastic leukemia. Hematology. 2019;24:337–348. PubMed
Locatelli F, Whitlock JA, Peters C, et al. . Blinatumomab versus historical standard therapy in pediatric patients with relapsed/refractory Ph-negative B-cell precursor acute lymphoblastic leukemia. Leukemia. 2020;34:2473–2478. PubMed PMC
Foà R, Bassan R, Vitale A, et al. . Dasatinib-blinatumomab for Ph-positive acute lymphoblastic leukemia in adults. N Engl J Med. 2020;383:1613–1623. PubMed
Pocock R, Farah N, Richardson SE, et al. . Current and emerging therapeutic approaches for T-cell acute lymphoblastic leukaemia. Br J Haematol. 2021;194:28–43. PubMed
Wright GW, Huang DW, Phelan JD, et al. . A probabilistic classification tool for genetic subtypes of diffuse large B cell lymphoma with therapeutic implications. Cancer Cell. 2020;37:551–568.e14. PubMed PMC
Sha C, Barrans S, Cucco F, et al. . Molecular high-grade B-cell lymphoma: defining a poor-risk group that requires different approaches to therapy. J Clin Oncol. 2019;37:202–212. PubMed PMC
Chapuy B, Stewart C, Dunford AJ, et al. . Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes. Nat Med. 2018;24:679–690. PubMed PMC
Vitolo U, Trněný M, Belada D, et al. . Obinutuzumab or rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone in previously untreated diffuse large B-cell lymphoma. J Clin Oncol. 2017;35:3529–3537. PubMed
Davies A, Cummin TE, Barrans S, et al. . Gene-expression profiling of bortezomib added to standard chemoimmunotherapy for diffuse large B-cell lymphoma (REMoDL-B): an open-label, randomised, phase 3 trial. Lancet Oncol. 2019;20:649–662. PubMed PMC
Thieblemont C, Tilly H, Gomes da Silva M, et al. . Lenalidomide maintenance compared with placebo in responding elderly patients with diffuse large B-cell lymphoma treated with first-line rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone. J Clin Oncol. 2017;35:2473–2481. PubMed
Poeschel V, Held G, Ziepert M, et al. . Four versus six cycles of CHOP chemotherapy in combination with six applications of rituximab in patients with aggressive B-cell lymphoma with favourable prognosis (FLYER): a randomised, phase 3, non-inferiority trial. Lancet. 2019;394:2271–2281. PubMed
Dührsen U, Müller S, Hertenstein B, et al. . Positron emission tomography-guided therapy of aggressive Non-Hodgkin lymphomas (PETAL): a multicenter, randomized phase III trial. J Clin Oncol. 2018;36:2024–2034. PubMed
Le Gouill S, Ghesquières H, Oberic L, et al. . Obinutuzumab vs rituximab for advanced DLBCL: a PET-guided and randomized phase 3 study by LYSA. Blood. 2021;137:2307–2320. PubMed
Hutchings M, Morschhauser F, Iacoboni G, et al. . Glofitamab, a Novel, Bivalent CD20-Targeting T-Cell-Engaging Bispecific Antibody, Induces Durable Complete Remissions in Relapsed or Refractory B-Cell Lymphoma: a Phase I Trial. J Clin Oncol. 2021;39:1959–1970. PubMed PMC
Salles G, Duell J, González Barca E, et al. . Tafasitamab plus lenalidomide in relapsed or refractory diffuse large B-cell lymphoma (L-MIND): a multicentre, prospective, single-arm, phase 2 study. Lancet Oncol. 2020;21:978–988. PubMed
Morschhauser F, Flinn IW, Advani R, et al. . Polatuzumab vedotin or pinatuzumab vedotin plus rituximab in patients with relapsed or refractory non-Hodgkin lymphoma: final results from a phase 2 randomised study (ROMULUS). Lancet Haematol. 2019;6:e254–e265. PubMed
Tilly H, Morschhauser F, Bartlett NL, et al. . Polatuzumab vedotin in combination with immunochemotherapy in patients with previously untreated diffuse large B-cell lymphoma: an open-label, non-randomised, phase 1b-2 study. Lancet Oncol. 2019;20:998–1010. PubMed
Caimi PF, Ai W, Alderuccio JP, et al. . Loncastuximab tesirine in relapsed or refractory diffuse large B-cell lymphoma (LOTIS-2): a multicentre, open-label, single-arm, phase 2 trial. Lancet Oncol. 2021;22:790–800. PubMed
Minard-Colin V, Aupérin A, Pillon M, et al. . Rituximab for high-risk, mature B-cell Non-Hodgkin’s lymphoma in children. N Engl J Med. 2020;382:2207–2219. PubMed PMC
Au-Yeung RKH, Arias Padilla L, Zimmermann M, et al. . Experience with provisional WHO-entities large B-cell lymphoma with IRF4-rearrangement and Burkitt-like lymphoma with 11q aberration in paediatric patients of the NHL-BFM group. Br J Haematol. 2020;190:753–763. PubMed
Swerdlow SH, Campo E, Pileri SA, et al. . The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016;127:2375–2390. PubMed PMC
Le Gouill S, Thieblemont C, Oberic L, et al. . Rituximab after autologous stem-cell transplantation in mantle-cell lymphoma. N Engl J Med. 2017;377:1250–1260. PubMed
Ladetto M, Ferrero S, Evangelista A, et al. . Lenalidomide maintenance after autologous transplantation prolongs PFS in young MCL patients: results of the randomized phase III MCL 0208 trial from Fondazione Italiana Linfomi (FIL). Blood. 2018;132(suppl 1):401.
Ribrag V, Safar V, Kluin-Nelemans H, et al. . Rituximab-Lenalidomide(R2) maintenance is superior to rituximab maintenance after first line immunochemotherapy in mantle cell lymphoma: results of the MCL R2 elderly clinical trial. Blood. 2021;138(suppl 1):379.
Giné E, de la Cruz F, Jiménez Ubieto A, et al. . Ibrutinib in combination with rituximab for indolent clinical forms of mantle cell lymphoma (IMCL-2015): a multicenter, open-label, single-arm, phase II trial. J Clin Oncol. 2022;40:1196–1205. PubMed PMC
Visco C, Tabanelli V, Peracchio C, et al. . Rituximab, bendamustine and cytarabine followed By venetoclax (V-RBAC) in high-risk elderly patients with mantle cell lymphoma. Blood. 2021;138(suppl 1):2427.
Hess G, Karola W, LaRosee P, et al. . Temsirolimus in combination with bendamustine and rituximab (BeRT) for the treatment of relapsed mantle cell and follicular lymphoma: final phase I/II results. Blood. 2016;128:2977.
Jerkeman M, Eskelund CW, Hutchings M, et al. . Ibrutinib, lenalidomide, and rituximab in relapsed or refractory mantle cell lymphoma (PHILEMON): a multicentre, open-label, single-arm, phase 2 trial. Lancet Haematol. 2018;5:e109–e116. PubMed
Jerkeman M, Kolstad A, Niemann CU, et al. . Venetoclax, lenalidomide and rituximab for patients with relapsed or refractory mantle cell lymphoma—data from the nordic lymphoma group NLG-MCL7 (VALERIA) phase I trial: stopping treatment in molecular remission is feasible. Blood. 2020;136(suppl 1):15.
Le Gouill S, Morschhauser F, Chiron D, et al. . Ibrutinib, obinutuzumab, and venetoclax in relapsed and untreated patients with mantle cell lymphoma: a phase ½ trial. Blood. 2021;137:877–887. PubMed
Nadeu F, Martin-Garcia D, Clot G, et al. . Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypes. Blood. 2020;136:1419–1432. PubMed PMC
Ferrero S, Rossi D, Rinaldi A, et al. . KMT2D mutations and TP53 disruptions are poor prognostic biomarkers in mantle cell lymphoma receiving high-dose therapy: a FIL study. Haematologica. 2020;105:1604–1612. PubMed PMC
Eskelund CW, Dahl C, Hansen JW, et al. . TP53 mutations identify younger mantle cell lymphoma patients who do not benefit from intensive chemoimmunotherapy. Blood. 2017;130:1903–1910. PubMed
Malarikova D, Berkova A, Obr A, et al. . Concurrent TP53 and CDKN2A gene aberrations in newly diagnosed mantle cell lymphoma correlate with chemoresistance and call for innovative upfront therapy. Cancers (Basel). 2020;12:E2120. PubMed PMC
Dreyling M, Ladetto M, Doorduijn JK, et al. . Triangle: autologous transplantation after a Rituximab/Ibrutinib/ara-c containing induction in generalized mantle cell lymphoma—a randomized European MCL Network Trial. Blood. 2019;134(suppl 1):2816.
Smith A, Crouch S, Lax S, et al. . Lymphoma incidence, survival and prevalence 2004-2014: sub-type analyses from the UK’s Haematological Malignancy Research Network. Br J Cancer. 2015;112:1575–1584. PubMed PMC
Dreyling M, Ghielmini M, Rule S, et al. . Newly diagnosed and relapsed follicular lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2021;32:298–308. PubMed
Pastore A, Jurinovic V, Kridel R, et al. . Integration of gene mutations in risk prognostication for patients receiving first-line immunochemotherapy for follicular lymphoma: a retrospective analysis of a prospective clinical trial and validation in a population-based registry. Lancet Oncol. 2015;16:1111–1122. PubMed
Bachy E, Maurer MJ, Habermann TM, et al. . A simplified scoring system in de novo follicular lymphoma treated initially with immunochemotherapy. Blood. 2018;132:49–58. PubMed PMC
Huet S, Tesson B, Jais JP, et al. . A gene-expression profiling score for prediction of outcome in patients with follicular lymphoma: a retrospective training and validation analysis in three international cohorts. Lancet Oncol. 2018;19:549–561. PubMed PMC
Bachy E, Seymour JF, Feugier P, et al. . Sustained progression-free survival benefit of rituximab maintenance in patients with follicular lymphoma: long-term results of the PRIMA study. J Clin Oncol. 2019;37:2815–2824. PubMed PMC
Marcus R, Davies A, Ando K, et al. . Obinutuzumab for the first-line treatment of follicular lymphoma. N Engl J Med. 2017;377:1331–1344. PubMed
Leonard JP, Trneny M, Izutsu K, et al. . AUGMENT: a phase III study of lenalidomide plus rituximab versus placebo plus rituximab in relapsed or refractory indolent lymphoma. J Clin Oncol. 2019;37:1188–1199. PubMed PMC
Heward J, Konali L, D’Avola A, et al. . KDM5 inhibition offers a novel therapeutic strategy for the treatment of KMT2D mutant lymphomas. Blood. 2021;138:370–381. PubMed PMC
Ortega-Molina A, Deleyto-Seldas N, Carreras J, et al. . Oncogenic Rag GTPase signaling enhances B cell activation and drives follicular lymphoma sensitive to pharmacological inhibition of mTOR. Nat Metab. 2019;1:775–789. PubMed PMC
Horton SJ, Giotopoulos G, Yun H, et al. . Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors. Nat Cell Biol. 2017;19:1093–1104. PubMed PMC
Bararia D, Hildebrand JA, Stolz S, et al. . Cathepsin S alterations induce a tumor-promoting immune microenvironment in follicular lymphoma. Cell Rep. 2020;31:107522. PubMed
Milpied P, Cervera-Marzal I, Mollichella ML, et al. . Human germinal center transcriptional programs are de-synchronized in B cell lymphoma. Nat Immunol. 2018;19:1013–1024. PubMed
Stevens WBC, Mendeville M, Redd R, et al. . Prognostic relevance of CD163 and CD8 combined with EZH2 and gain of chromosome 18 in follicular lymphoma: a study by the Lunenburg Lymphoma Biomarker Consortium. Haematologica. 2017;102:1413–1423. PubMed PMC
Mourcin F, Verdiére L, Roulois D, et al. . Follicular lymphoma triggers phenotypic and functional remodeling of the human lymphoid stromal cell landscape. Immunity. 2021;54:1901. PubMed
Araf S, Wang J, Korfi K, et al. . Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma. Leukemia. 2018;32:1261–1265. PubMed PMC
Mozas P, Rivero A, López-Guillermo A. Past, present and future of prognostic scores in follicular lymphoma. Blood Rev. 2021;50:100865. PubMed
Nagy Á, Bátai B, Balogh A, et al. . Quantitative analysis and monitoring of EZH2 mutations using liquid biopsy in follicular lymphoma. Genes (Basel). 2020;11:E785. PubMed PMC
Delfau-Larue MH, van der Gucht A, Dupuis J, et al. . Total metabolic tumor volume, circulating tumor cells, cell-free DNA: distinct prognostic value in follicular lymphoma. Blood Adv. 2018;2:807–816. PubMed PMC
Cascione L, Rinaldi A, Bruscaggin A, et al. . Novel insights into the genetics and epigenetics of MALT lymphoma unveiled by next generation sequencing analyses. Haematologica. 2019;104:e558–e561. PubMed PMC
Moody S, Thompson JS, Chuang SS, et al. . Novel GPR34 and CCR6 mutation and distinct genetic profiles in MALT lymphomas of different sites. Haematologica. 2018;103:1329–1336. PubMed PMC
Wu F, Watanabe N, Tzioni MM, et al. . Thyroid MALT lymphoma: self-harm to gain potential T-cell help. Leukemia. 2021;35:3497–3508. PubMed PMC
Kiesewetter B, Copie-Bergman C, Levy M, et al. . Genetic characterization and clinical features of helicobacter pylori negative gastric mucosa-associated lymphoid tissue lymphoma. Cancers (Basel). 2021;13:2993. PubMed PMC
Bikos V, Karypidou M, Stalika E, et al. . An immunogenetic signature of ongoing antigen interactions in splenic marginal zone lymphoma expressing IGHV1-2*04 receptors. Clin Cancer Res. 2016;22:2032–2040. PubMed
Xochelli A, Bikos V, Polychronidou E, et al. . Disease-biased and shared characteristics of the immunoglobulin gene repertoires in marginal zone B cell lymphoproliferations. J Pathol. 2019;247:416–421. PubMed
Agathangelidis A, Xochelli A, Stamatopoulos K. A gene is known by the company it keeps: enrichment of TNFAIP3 gene aberrations in MALT lymphomas expressing IGHV4-34 antigen receptors. J Pathol. 2017;243:403–406. PubMed
Parry M, Rose-Zerilli MJ, Ljungström V, et al. . Genetics and prognostication in splenic marginal zone lymphoma: revelations from deep sequencing. Clin Cancer Res. 2015;21:4174–4183. PubMed PMC
Moody S, Escudero-Ibarz L, Wang M, et al. . Significant association between TNFAIP3 inactivation and biased immunoglobulin heavy chain variable region 4-34 usage in mucosa-associated lymphoid tissue lymphoma. J Pathol. 2017;243:3–8. PubMed
Thieblemont C, Cascione L, Conconi A, et al. . A MALT lymphoma prognostic index. Blood. 2017;130:1409–1417. PubMed
Conconi A, Thieblemont C, Cascione L, et al. . Early progression of disease predicts shorter survival in MALT lymphoma patients receiving systemic treatment. Haematologica. 2020;105:2592–2597. PubMed PMC
Zucca E, Conconi A, Martinelli G, et al. . Final results of the IELSG-19 randomized trial of mucosa-associated lymphoid tissue lymphoma: improved event-free and progression-free survival with rituximab plus chlorambucil versus either chlorambucil or rituximab monotherapy. J Clin Oncol. 2017;35:1905–1912. PubMed
Salar A, Domingo-Domenech E, Panizo C, et al. . Long-term results of a phase 2 study of rituximab and bendamustine for mucosa-associated lymphoid tissue lymphoma. Blood. 2017;130:1772–1774. PubMed
Kiesewetter B, Willenbacher E, Willenbacher W, et al. . A phase 2 study of rituximab plus lenalidomide for mucosa-associated lymphoid tissue lymphoma. Blood. 2017;129:383–385. PubMed
Kiesewetter B, Lamm W, Neuper O, et al. . Prolonged follow-up on lenalidomide-based treatment for mucosa-associated lymphoid tissue lymphoma (MALT lymphoma)-Real-world data from the Medical University of Vienna. Hematol Oncol. 2019;37:345–351. PubMed PMC
Becnel MR, Nastoupil LJ, Samaniego F, et al. . Lenalidomide plus rituximab (R2) in previously untreated marginal zone lymphoma: subgroup analysis and long-term follow-up of an open-label phase 2 trial. Br J Haematol. 2019;185:874–882. PubMed PMC
Zucca E, Arcaini L, Buske C, et al. . Marginal zone lymphomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2020;31:17–29. PubMed
Vannata B, Vanazzi A, Negri M, et al. . A phase II trial of bendamustine in combination with ofatumumab in patients with relapsed or refractory marginal zone B-cell lymphomas. Hematol Oncol. 2021;39:60–65. PubMed
Kiesewetter B, Neuper O, Mayerhoefer ME, et al. . A pilot phase II study of ofatumumab monotherapy for extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) lymphoma. Hematol Oncol. 2018;36:49–55. PubMed
Panayiotidis P, Follows GA, Mollica L, et al. . Efficacy and safety of copanlisib in patients with relapsed or refractory marginal zone lymphoma. Blood Adv. 2021;5:823–828. PubMed PMC
Iannitto E, Bellei M, Amorim S, et al. . Efficacy of bendamustine and rituximab in splenic marginal zone lymphoma: results from the phase II BRISMA/IELSG36 study. Br J Haematol. 2018;183:755–765. PubMed
Stathis A, Gregorini A, Gressin R, et al. . IELSG-38: a phase II study of chlorambucil in combination with rituximab followed By maintenance therapy with subcutaneous rituximab in patients with extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue (MALT). Blood. 2017;130(suppl 1):1506.
Frigeni M, Besson C, Visco C, et al. . Interferon-free compared to interferon-based antiviral regimens as first-line therapy for B-cell lymphoproliferative disorders associated with hepatitis C virus infection. Leukemia. 2020;34:1462–1466. PubMed
Ferreri AJM, Sassone M, Miserocchi E, et al. . Treatment of MALT lymphoma of the conjunctiva with intralesional rituximab supplemented with autologous serum. Blood Adv. 2020;4:1013–1019. PubMed PMC
Leblond V, Treon SP, Dimopoulos MA. Waldenström’s macroglobulinemia. Switzerland: Springer International Publishing; 2017.
Ouk C, Roland L, Gachard N, et al. . Continuous MYD88 activation is associated with expansion and then transformation of IgM differentiating plasma cells. Front Immunol. 2021;12:641692. PubMed PMC
Leblond V, Johnson S, Chevret S, et al. . Results of a randomized trial of chlorambucil versus fludarabine for patients with untreated Waldenström macroglobulinemia, marginal zone lymphoma, or lymphoplasmacytic lymphoma. J Clin Oncol. 2013;31:301–307. PubMed
Treon SP, Tripsas CK, Meid K, et al. . Ibrutinib in previously treated Waldenström’s macroglobulinemia. N Engl J Med. 2015;372:1430–1440. PubMed
Dimopoulos MA, Tedeschi A, Trotman J, et al. . Phase 3 trial of Ibrutinib plus rituximab in Waldenström’s macroglobulinemia. N Engl J Med. 2018;378:2399–2410. PubMed
Kurtz DM, Esfahani MS, Scherer F, et al. . Dynamic risk profiling using serial tumor biomarkers for personalized outcome prediction. Cell. 2019;178:699–713.e19. PubMed PMC
Eichhorst B, Robak T, Montserrat E, et al. . Chronic lymphocytic leukaemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2021;32:23–33. PubMed
Hallek M, Cheson BD, Catovsky D, et al. . iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL. Blood. 2018;131:2745–2760. PubMed
Zapatka M, Tausch E, Öztürk S, et al. . Clonal evolution in chronic lymphocytic leukemia is scant in relapsed but accelerated in refractory cases after chemo(immune) therapy. Haematologica. 2022;107:604–614. PubMed PMC
Knisbacher B, Lin Z, Hahn CK, et al. . Molecular map of chronic lymphocytic leukemia and its impact on outcome. Nat Genet. 2022. [In Press]. PubMed PMC
Al-Sawaf O, Zhang C, Tandon M, et al. . Venetoclax plus obinutuzumab versus chlorambucil plus obinutuzumab for previously untreated chronic lymphocytic leukaemia (CLL14): follow-up results from a multicentre, open-label, randomised, phase 3 trial. Lancet Oncol. 2020;21:1188–1200. PubMed
International CLL-IPI working group. An international prognostic index for patients with chronic lymphocytic leukaemia (CLL-IPI): a meta-analysis of individual patient data. Lancet Oncol. 2016;17:779–790. PubMed
Rawstron AC, Kreuzer KA, Soosapilla A, et al. . Reproducible diagnosis of chronic lymphocytic leukemia by flow cytometry: an European Research Initiative on CLL (ERIC) & European Society for Clinical Cell Analysis (ESCCA) Harmonisation project. Cytometry B Clin Cytom. 2018;94:121–128. PubMed PMC
Rosenquist R, Ghia P, Hadzidimitriou A, et al. . Immunoglobulin gene sequence analysis in chronic lymphocytic leukemia: updated ERIC recommendations. Leukemia. 2017;31:1477–1481. PubMed PMC
Agathangelidis A, Chatzidimitriou A, Gemenetzi K, et al. . Higher-order connections between stereotyped subsets: implications for improved patient classification in CLL. Blood. 2021;137:1365–1376. PubMed PMC
Minici C, Gounari M, Übelhart R, et al. . Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia. Nat Commun. 2017;8:15746. PubMed PMC
Malcikova J, Tausch E, Rossi D, et al. . ERIC recommendations for TP53 mutation analysis in chronic lymphocytic leukemia-update on methodological approaches and results interpretation. Leukemia. 2018;32:1070–1080. PubMed PMC
Baliakas P, Jeromin S, Iskas M, et al. . Cytogenetic complexity in chronic lymphocytic leukemia: definitions, associations, and clinical impact. Blood. 2019;133:1205–1216. PubMed PMC
Tausch E, Schneider C, Robrecht S, et al. . Prognostic and predictive impact of genetic markers in patients with CLL treated with obinutuzumab and venetoclax. Blood. 2020;135:2402–2412. PubMed
Condoluci A, Rossi D. Richter Syndrome. Curr Oncol Rep. 2021;23:26. PubMed PMC
Gribben JG, Bosch F, Cymbalista F, et al. . Optimising outcomes for patients with chronic lymphocytic leukaemia on ibrutinib therapy: European recommendations for clinical practice. Br J Haematol. 2018;180:666–679. PubMed
Scarfò L, Chatzikonstantinou T, Rigolin GM, et al. . COVID-19 severity and mortality in patients with chronic lymphocytic leukemia: a joint study by ERIC, the European Research Initiative on CLL, and CLL Campus. Leukemia. 2020;34:2354–2363. PubMed PMC
Horwitz S, O’Connor OA, Pro B, et al. . Brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma (ECHELON-2): a global, double-blind, randomised, phase 3 trial. Lancet. 2019;393:229–240. PubMed PMC
Bachy E, Camus V, Thieblemont C, et al. . Final analysis of the Ro-CHOP phase III study (Conducted by LYSA): romidepsin plus CHOP in patients with peripheral T-cell lymphoma. Blood. 2020;136(suppl 1):32–33. PubMed
Lemonnier F, Safar V, Beldi-Ferchiou A, et al. . Integrative analysis of a phase 2 trial combining lenalidomide with CHOP in angioimmunoblastic T-cell lymphoma. Blood Adv. 2021;5:539–548. PubMed PMC
Fossard G, Broussais F, Coelho I, et al. . Role of up-front autologous stem-cell transplantation in peripheral T-cell lymphoma for patients in response after induction: an analysis of patients from LYSA centers. Ann Oncol. 2018;29:715–723. PubMed
Schmitz N, Truemper L, Bouabdallah K, et al. . A randomized phase 3 trial of autologous vs allogeneic transplantation as part of first-line therapy in poor-risk peripheral T-NHL. Blood. 2021;137:2646–2656. PubMed PMC
Maciocia PM, Wawrzyniecka PA, Philip B, et al. . Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies. Nat Med. 2017;23:1416–1423. PubMed
Fox CP, Civallero M, Ko YH, et al. . Survival outcomes of patients with extranodal natural-killer T-cell lymphoma: a prospective cohort study from the international T-cell Project. Lancet Haematol. 2020;7:e284–e294. PubMed
Dobay MP, Lemonnier F, Missiaglia E, et al. . Integrative clinicopathological and molecular analyses of angioimmunoblastic T-cell lymphoma and other nodal lymphomas of follicular helper T-cell origin. Haematologica. 2017;102:e148–e151. PubMed PMC
Vallois D, Dobay MP, Morin RD, et al. . Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell-derived lymphomas. Blood. 2016;128:1490–1502. PubMed
Debackere K, Marcelis L, Demeyer S, et al. . Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified. Nat Commun. 2021;12:3705. PubMed PMC
Heavican TB, Bouska A, Yu J, et al. . Genetic drivers of oncogenic pathways in molecular subgroups of peripheral T-cell lymphoma. Blood. 2019;133:1664–1676. PubMed PMC
Roberti A, Dobay MP, Bisig B, et al. . Type II enteropathy-associated T-cell lymphoma features a unique genomic profile with highly recurrent SETD2 alterations. Nat Commun. 2016;7:12602. PubMed PMC
McKinney M, Moffitt AB, Gaulard P, et al. . The genetic basis of hepatosplenic T-cell lymphoma. Cancer Discov. 2017;7:369–379. PubMed PMC
Laurent C, Delas A, Gaulard P, et al. . Breast implant-associated anaplastic large cell lymphoma: two distinct clinicopathological variants with different outcomes. Ann Oncol. 2016;27:306–314. PubMed PMC
Laurent C, Nicolae A, Laurent C, et al. . Gene alterations in epigenetic modifiers and JAK-STAT signaling are frequent in breast implant-associated ALCL. Blood. 2020;135:360–370. PubMed PMC
de Leval L. Chromosomes in breast lymphoma. Blood. 2020;136:2848–2849. PubMed
Drieux F, Ruminy P, Abdel-Sater A, et al. . Defining signatures of peripheral T-cell lymphoma with a targeted 20-marker gene expression profiling assay. Haematologica. 2020;105:1582–1592. PubMed PMC
Drieux F, Ruminy P, Sater V, et al. . Detection of gene fusion transcripts in peripheral T-cell lymphoma using a multiplexed targeted sequencing assay. J Mol Diagn. 2021;23:929–940. PubMed
Carbone A, Vaccher E, Gloghini A. Hematologic cancers in individuals infected by HIV. Blood. 2022;139:995–1012. PubMed
Carbone A, Gloghini A, Serraino D, et al. . Immunodeficiency-associated Hodgkin lymphoma. Expert Rev Hematol. 2021;14:547–559. PubMed
Ambinder RF. Epstein-barr virus-associated post-transplant lymphoproliferative disease. Recent Results Cancer Res. 2021;217:197–207. PubMed
Noy A. Optimizing treatment of HIV-associated lymphoma. Blood. 2019;134:1385–1394. PubMed PMC
Ohmoto A, Fuji S. Clinical features and treatment strategies for post-transplant and iatrogenic immunodeficiency-associated lymphoproliferative disorders. Blood Rev. 2021;49:100807. PubMed
Shah N, Eyre TA, Tucker D, et al. . Front-line management of post-transplantation lymphoproliferative disorder in adult solid organ recipient patients—A British Society for Haematology Guideline. Br J Haematol. 2021;193:727–740. PubMed
Alderuccio JP, Olszewski AJ, Evens AM, et al. . HIV-associated Burkitt lymphoma: outcomes from a US-UK collaborative analysis. Blood Adv. 2021;5:2852–2862. PubMed PMC
Eyre TA, Caillard S, Finel H, et al. . Autologous stem cell transplantation for post-transplant lymphoproliferative disorders after solid organ transplantation: a retrospective analysis from the Lymphoma Working Party of the EBMT. Bone Marrow Transplant. 2021;56:2118–2124. PubMed PMC
Allred J, Bharucha K, Özütemiz C, et al. . Chimeric antigen receptor T-cell therapy for HIV-associated diffuse large B-cell lymphoma: case report and management recommendations. Bone Marrow Transplant. 2021;56:679–682. PubMed PMC
Munshi NC, Avet-Loiseau H, Anderson KC, et al. . A large meta-analysis establishes the role of MRD negativity in long-term survival outcomes in patients with multiple myeloma. Blood Adv. 2020;4:5988–5999. PubMed PMC
Zamagni E, Nanni C, Dozza L, et al. . Standardization of 18F-FDG-PET/CT according to deauville criteria for metabolic complete response definition in newly diagnosed multiple myeloma. J Clin Oncol. 2021;39:116–125. PubMed
Zamagni E, Nanni C, Gay F, et al. . MRD evaluation By PET/CT according to deauville criteria combined with multiparameter flow cytometry in newly diagnosed transplant eligible multiple myeloma (MM) patients enrolled in the phase II randomized forte trial. Blood. 2019;134(suppl 1):4321–4321.
Kumar S, Paiva B, Anderson KC, et al. . International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myeloma. Lancet Oncol. 2016;17:e328–e346. PubMed
Cohen AD. Myeloma: next generation immunotherapy. Hematology Am Soc Hematol Educ Program. 2019;2019:266–272. PubMed PMC
Munshi NC, Anderson LD, Jr, Shah N, et al. . Idecabtagene vicleucel in relapsed and refractory multiple myeloma. N Engl J Med. 2021;384:705–716. PubMed
Berdeja JG, Madduri D, Usmani SZ, et al. . Ciltacabtagene autoleucel, a B-cell maturation antigen-directed chimeric antigen receptor T-cell therapy in patients with relapsed or refractory multiple myeloma (CARTITUDE-1): a phase 1b/2 open-label study. Lancet. 2021;398:314–324. PubMed
van de Donk N, Pawlyn C, Yong KL. Multiple myeloma. Lancet. 2021;397:410–427. PubMed
Gandhi UH, Cornell RF, Lakshman A, et al. . Outcomes of patients with multiple myeloma refractory to CD38-targeted monoclonal antibody therapy. Leukemia. 2019;33:2266–2275. PubMed PMC
Chalopin T, Vallet N, Theisen O, et al. . No survival improvement in patients with high-risk multiple myeloma harbouring del(17p) and/or t(4;14) over the two past decades. Br J Haematol. 2021;194:635–638. PubMed
Palumbo A, Bringhen S, Mateos MV, et al. . Geriatric assessment predicts survival and toxicities in elderly myeloma patients: an International Myeloma Working Group report. Blood. 2015;125:2068–2074. PubMed PMC
Corre J, Perrot A, Caillot D, et al. . del(17p) without TP53 mutation confers a poor prognosis in intensively treated newly diagnosed patients with multiple myeloma. Blood. 2021;137:1192–1195. PubMed PMC
Larocca A, Bonello F, Gaidano G, et al. . Dose/schedule-adjusted Rd-R vs continuous Rd for elderly, intermediate-fit patients with newly diagnosed multiple myeloma. Blood. 2021;137:3027–3036. PubMed
Stege CAM, Nasserinejad K, van der Spek E, et al. . Ixazomib, daratumumab, and low-dose dexamethasone in frail patients with newly diagnosed multiple myeloma: the hovon 143 study. J Clin Oncol. 2021;39:2758–2767. PubMed
Avet-Loiseau H, San-Miguel J, Casneuf T, et al. . Evaluation of sustained minimal residual disease negativity with daratumumab-combination regimens in relapsed and/or refractory multiple myeloma: analysis of POLLUX and CASTOR. J Clin Oncol. 2021;39:1139–1149. PubMed PMC
Bertamini L, D’Agostino M, Gay F. MRD assessment in multiple myeloma: progress and challenges. Curr Hematol Malig Rep. 2021;16:162–171. PubMed
Abeykoon JP, Murray DL, Murray I, et al. . Implications of detecting serum monoclonal protein by MASS-fix following stem cell transplantation in multiple myeloma. Br J Haematol. 2021;193:380–385. PubMed
Holthof LC, Stikvoort A, van der Horst HJ, et al. . Bone marrow mesenchymal stromal cell-mediated resistance in multiple myeloma against NK cells can be overcome by introduction of CD38-CAR or TRAIL-variant. HemaSphere. 2021;5:e561. PubMed PMC
Depil S, Duchateau P, Grupp SA, et al. . ‘Off-the-shelf’ allogeneic CAR T cells: development and challenges. Nat Rev Drug Discov. 2020;19:185–199. PubMed
Corre J, Munshi NC, Avet-Loiseau H. Risk factors in multiple myeloma: is it time for a revision? Blood. 2021;137:16–19. PubMed PMC
Cavo M, Gay F, Beksac M, et al. . Autologous haematopoietic stem-cell transplantation versus bortezomib-melphalan-prednisone, with or without bortezomib-lenalidomide-dexamethasone consolidation therapy, and lenalidomide maintenance for newly diagnosed multiple myeloma (EMN02/HO95): a multicentre, randomised, open-label, phase 3 study. Lancet Haematol. 2020;7:e456–e468. PubMed
Brown S, Sherratt D, Hinsley S, et al. ; Myeloma UK Early Phase Clinical Trial Network. MUKnine OPTIMUM protocol: a screening study to identify high-risk patients with multiple myeloma suitable for novel treatment approaches combined with a phase II study evaluating optimised combination of biological therapy in newly diagnosed high-risk multiple myeloma and plasma cell leukaemia. BMJ Open. 2021;11:e046225. PubMed PMC
D’Agostino M, Larocca A, Offidani M, et al. . Octogenarian newly diagnosed multiple myeloma patients without geriatric impairments: the role of age >80 in the IMWG frailty score. Blood Cancer J. 2021;11:73. PubMed PMC
Stege CAM, Nasserinejad K, Klein SK, et al. . Improving the identification of frail elderly newly diagnosed multiple myeloma patients. Leukemia. 2021;35:2715–2719. PubMed
Prasad V, De Jesús K, Mailankody S. The high price of anticancer drugs: origins, implications, barriers, solutions. Nat Rev Clin Oncol. 2017;14:381–390. PubMed
Bhattacharya K, Bentley JP, Ramachandran S, et al. . Phase-specific and lifetime costs of multiple myeloma among older adults in the US. JAMA Netw Open. 2021;4:e2116357. PubMed PMC
Blommestein HM, Franken MG, van Beurden-Tan CHY, et al. . Cost-effectiveness of novel treatment sequences for transplant-ineligible patients with multiple myeloma. JAMA Netw Open. 2021;4:e213497. PubMed PMC