Disease-biased and shared characteristics of the immunoglobulin gene repertoires in marginal zone B cell lymphoproliferations
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
15019
Blood Cancer UK - United Kingdom
PubMed
30484876
DOI
10.1002/path.5209
Knihovny.cz E-zdroje
- Klíčová slova
- antigen, immunoglobulin gene, marginal zone lymphoma, ontogeny,
- MeSH
- genová přestavba B-lymfocytů genetika MeSH
- geny pro imunoglobuliny genetika MeSH
- geny pro těžké řetězce imunoglobulinů genetika MeSH
- hypervariabilní oblasti genetika MeSH
- lidé MeSH
- lymfom z B-buněk marginální zóny genetika MeSH
- mutace genetika MeSH
- nádorové mikroprostředí MeSH
- receptory antigenů B-buněk genetika MeSH
- variabilní oblast imunoglobulinu genetika MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- hypervariabilní oblasti MeSH
- receptory antigenů B-buněk MeSH
- variabilní oblast imunoglobulinu MeSH
The B cell receptor immunoglobulin (Ig) gene repertoires of marginal zone (MZ) lymphoproliferations were analyzed in order to obtain insight into their ontogenetic relationships. Our cohort included cases with MZ lymphomas (n = 488), i.e. splenic (SMZL), nodal (NMZL) and extranodal (ENMZL), as well as provisional entities (n = 76), according to the WHO classification. The most striking Ig gene repertoire skewing was observed in SMZL. However, restrictions were also identified in all other MZ lymphomas studied, particularly ENMZL, with significantly different Ig gene distributions depending on the primary site of involvement. Cross-entity comparisons of the MZ Ig sequence dataset with a large dataset of Ig sequences (MZ-related or not; n = 65 837) revealed four major clusters of cases sharing homologous ('public') heavy variable complementarity-determining region 3. These clusters included rearrangements from SMZL, ENMZL (gastric, salivary gland, ocular adnexa), chronic lymphocytic leukemia, but also rheumatoid factors and non-malignant splenic MZ cells. In conclusion, different MZ lymphomas display biased immunogenetic signatures indicating distinct antigen exposure histories. The existence of rare public stereotypes raises the intriguing possibility that common, pathogen-triggered, immune-mediated mechanisms may result in diverse B lymphoproliferations due to targeting versatile progenitor B cells and/or operating in particular microenvironments. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
1st Department of Propaedeutic Medicine University of Athens Athens Greece
Central European Institute of Technology Masaryk University Brno Czech Republic
Centre for Cancer Research and Cell Biology Queen's University Belfast Belfast UK
Department of Haematology Athens Medical Center Athens Greece
Department of Haematology Royal Bournemouth Hospital Bournemouth UK
Department of Haematology University of Crete Heraklion Greece
Department of Hematology Hopital Pitie Salpetriere and Sorbonne University Paris France
Department of Immunology Genetics and Pathology Uppsala University Uppsala Sweden
Department of Informatics Ionian University Corfu Greece
Department of Molecular Medicine and Surgery Karolinska Institutet Stockholm Sweden
Department of Pathology and Hematology Hospices Civils de Lyon Universite Lyon 1 Lyon France
Department of Pathology Hopital Pitie Salpetriere and Sorbonne University Paris France
Department of Pathology Radboud University Medical Center Nijmegen The Netherlands
Hematology Department and HCT Unit G Papanicolaou Hospital Thessaloniki Greece
Hematology Department Nikea General Hospital Piraeus Greece
Hematopathology Department Evangelismos Hospital Athens Greece
Hospital Virgen de la Salud Toledo Spain
Information Technologies Institute CERTH Thessaloniki Greece
Institute of Applied Biosciences CERTH Thessaloniki Greece
Molecular Pathology Ospedale Policlinico SanMartino Genoa Italy
Pathology Department IIS 'Fundacion Jimenez Diaz' Madrid Spain
Pathology Unit San Raffaele Scientific Institute Milan Italy
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