Embryotoxicity of 25 psychotropic drugs: a study using CHEST
Language English Country United States Media print
Document type Journal Article
- MeSH
- Embryo, Mammalian drug effects MeSH
- Cardiovascular System drug effects MeSH
- Rabbits MeSH
- Rats MeSH
- Chick Embryo MeSH
- Mice MeSH
- Psychotropic Drugs toxicity MeSH
- Heart Arrest chemically induced physiopathology MeSH
- Pregnancy MeSH
- Teratogens toxicity MeSH
- Animals MeSH
- Check Tag
- Rabbits MeSH
- Rats MeSH
- Chick Embryo MeSH
- Mice MeSH
- Pregnancy MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Psychotropic Drugs MeSH
- Teratogens MeSH
Twenty five psychotropic drugs were ranked according to the embryotoxicity dose ranges estimated by the Chick Embryotoxicity Screening Test (CHEST). The chick results were compared with some data for common laboratory mammals. In 17 psychotropic drugs a deleterious dose-dependent effect upon the embryonic cardiovascular system was disclosed, terminating in immediate cardiac arrest.
References provided by Crossref.org
Development of nucleolar apparatus in the chick primitive erythroid cells