Vliv aminokyselin na metabolity neurotransmiterů v likvoru
[The effect of amino acids on neurotransmitter metabolites in the cerebrospinal fluid]
Language Czech Country Czech Republic Media print
Document type Case Reports, English Abstract, Journal Article
PubMed
1712669
- MeSH
- Infant MeSH
- Homovanillic Acid cerebrospinal fluid MeSH
- Hydroxyindoleacetic Acid cerebrospinal fluid MeSH
- Humans MeSH
- Child, Preschool MeSH
- Tryptophan pharmacology MeSH
- Tyrosine pharmacology MeSH
- Check Tag
- Infant MeSH
- Humans MeSH
- Male MeSH
- Child, Preschool MeSH
- Female MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Case Reports MeSH
- Names of Substances
- Homovanillic Acid MeSH
- Hydroxyindoleacetic Acid MeSH
- Tryptophan MeSH
- Tyrosine MeSH
Metabolites of neurotransmitters of dopamine, homomovanillic acid (HVA), and of serotonin, 5-hydroxyindole acetic acid (5-HIAA), were assessed in cerebrospinal fluid by the method of high pressure liquid chromatography with electrochemical detection. The HVA concentration in cerebrospinal fluid rose markedly in a two-month-old infant with intracranial hypertension caused by a communicating hyporesorptive hydrocephalus following administration of tyrosine, the precursor of dopamine. The 5-HIAA concentration in cerebrospinal fluid rose significantly in a 20-month-old boy with epilepsy and arrested psychomotor development after administration of 5-hydroxytryptophan, the precursor of dopamine. Biochemical normalization of concentrations of neurotransmiteed metabolites did not lead to changes in the clinical condition of the children.
