Macrotetrolides isolated from a new producer, Streptomyces globisporus, were identified as nonactin, monactin, dinactin and trinactin. Spectroscopic characterization of these compounds was extended by 13NMR spectra. Chemical ionization with ammonia as reactive gas was proposed for mass-spectroscopic characterization of their mixtures. Their biological activity was confirmed by using larvae of the Colorado potato beetle (Leptinotarsa decemlineata) as a new test model.

Institute of Microbiology Czechoslovak Academy of Sciences Prague

Zobrazit více v PubMed

J Antibiot (Tokyo). 1970 Feb;23(2):105-6 PubMed

Arzneimittelforschung. 1964 Apr;14 :356-60 PubMed

J Chromatogr. 1988 Jun 17;442:431-5 PubMed

J Antibiot (Tokyo). 1965 May;18:128-9 PubMed

Antibiotiki. 1973 Sep;18(9):777-80 PubMed

J Antibiot (Tokyo). 1975 Dec;28(12):1000-3 PubMed

Arch Mikrobiol. 1972;85(3):233-8 PubMed

Biochemistry. 1967 Feb;6(2):365-71 PubMed

J Antibiot (Tokyo). 1971 Jun;24(6):347-52 PubMed

J Antibiot (Tokyo). 1971 Jul;24(7):418-22 PubMed

Cytobios. 1989;58(233):85-91 PubMed

Appl Environ Microbiol. 1980 Aug;40(2):264-8 PubMed

Helv Chim Acta. 1967 Sep;50(7):1782-93 PubMed

Antimicrob Agents Chemother (Bethesda). 1966;6:644-50 PubMed

J Econ Entomol. 1972 Apr;65(2):372-5 PubMed

Arch Mikrobiol. 1972;85(3):239-48 PubMed

Compounds isolated at the Institute of Microbiology in 1989-2001 and future trends

Biological effects of macrotetrolide antibiotics and nonactic acids

Characteristics of Streptomyces globisporus strain 0234A forming endospores in submerged cultures