Differential modulation of leucocyte surface antigens by various inducers on the T-cell line MOLT-4
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
1830012
Knihovny.cz E-resources
- MeSH
- Leukocyte Common Antigens MeSH
- CD8 Antigens MeSH
- Antigens, Neoplasm analysis MeSH
- Antigens, Surface analysis MeSH
- Cell Line MeSH
- Antigens, CD analysis MeSH
- Antigens, Differentiation, T-Lymphocyte analysis MeSH
- Down-Regulation drug effects MeSH
- Histocompatibility Antigens analysis MeSH
- HLA Antigens analysis MeSH
- Interferon alpha-2 MeSH
- Interferon-alpha pharmacology MeSH
- Leukemia, T-Cell pathology MeSH
- Humans MeSH
- Tumor Cells, Cultured drug effects immunology MeSH
- Recombinant Proteins MeSH
- Drug Synergism MeSH
- T-Lymphocytes drug effects immunology MeSH
- Tetradecanoylphorbol Acetate pharmacology MeSH
- Up-Regulation drug effects MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Leukocyte Common Antigens MeSH
- CD8 Antigens MeSH
- Antigens, Neoplasm MeSH
- Antigens, Surface MeSH
- Antigens, CD MeSH
- Antigens, Differentiation, T-Lymphocyte MeSH
- Histocompatibility Antigens MeSH
- HLA Antigens MeSH
- Interferon alpha-2 MeSH
- Interferon-alpha MeSH
- Recombinant Proteins MeSH
- Tetradecanoylphorbol Acetate MeSH
Pretreatment of MOLT-4 T-cell line with 12-0-tetradecanoylphorbol 13-acetate (TPA) potentiated the interferon alpha-induced cell surface expression of class I HLA. Simultaneous combined action of TPA and rIFN-alpha resulted in a synergistic effect upon the up-regulation of class I HLA. Neither TPA nor rIFN modulated the cell surface expression of HLA class II (DR and DP) antigens. Leucocyte common antigen (CD45) cell surface expression was quantitatively increased on MOLT-4 cells by TPA induction, unaltered by rIFN and up-regulated by combined action of TPA and rIFN. CD8 antigen was down-regulated by both TPA and rIFN.
