Extent of the tetrodotoxin induced blockade examined by pupillary paralysis elicited by intracerebral injection of the drug
Language English Country Germany Media print
Document type Journal Article
PubMed
2026211
DOI
10.1007/bf00229849
Knihovny.cz E-resources
- MeSH
- Rats MeSH
- Microinjections MeSH
- Brain drug effects pathology physiopathology MeSH
- Mydriasis chemically induced physiopathology MeSH
- Oculomotor Nerve drug effects pathology physiopathology MeSH
- Pupil drug effects MeSH
- Stereotaxic Techniques MeSH
- Tetrodotoxin administration & dosage toxicity MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Tetrodotoxin MeSH
Spatial extent and duration of the functional blockade elicited by intracerebral injection of tetrodotoxin (TTX) was examined in rats anesthetized with pentobarbital. Pupillary diameter was measured under dissecting microscope before and up to 24 h after injection of TTX (10 ng/l microliters saline) into or 1.0, 1.5 and 2.0 mm lateral from the Edinger-Westphal nucleus. TTX administration elicited mydriasis the latency of which was directly and amplitude indirectly proportional to the target-injection distance. The maximum mydriasis attained 3.4 mm, lasted 2 h and slowly decayed over subsequent 20 h. Impulse transmission and conduction was blocked in a spherical volume of tissue about 3 mm in diameter the development of which could be approximated by diffusion from an instantaneous point source. Completeness and full reversibility make the TTX block a convenient research tool.
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