Mass spectrometric structure determination of metabolites of 3-[2-(N,N-dimethylaminomethyl)phenylthio]phenol
Language English Country Netherlands Media print
Document type Journal Article
- MeSH
- Serotonin Antagonists metabolism urine MeSH
- Benzylamines analysis metabolism urine MeSH
- Chromatography, Thin Layer MeSH
- Feces chemistry MeSH
- Mass Spectrometry MeSH
- Rats, Inbred Strains MeSH
- Rabbits MeSH
- Rats MeSH
- Mice MeSH
- Dogs MeSH
- Spectrophotometry, Infrared MeSH
- Animals MeSH
- Check Tag
- Rabbits MeSH
- Rats MeSH
- Male MeSH
- Mice MeSH
- Dogs MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Serotonin Antagonists MeSH
- Benzylamines MeSH
- VUBF 15468 MeSH Browser
Metabolites of 3-[2-(N,N-dimethylaminoethyl)phenylthio]phenol (I) were isolated from the urine of rats, mice, rabbit and dog and from the faeces of rats by extraction and thin-layer chromatography. From the mass spectrum of I and using characteristics mass shifts in the spectra of metabolites, the structures of four metabolites were determined, whereas for two other isomeric metabolites the structures were resolved by means of IR spectra. Conclusions regarding the structures derived from the spectra were confirmed by comparing them with synthetic standards. Generally, metabolic changes of I can be characterized by demethylation, hydroxylation combined with methylation, S-oxidation and by a combination of these metabolic reactions.
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