Mass spectrometric structure determination of metabolites of 3-[2-(N,N-dimethylaminomethyl)phenylthio]phenol
Jazyk angličtina Země Nizozemsko Médium print
Typ dokumentu časopisecké články
- MeSH
- antagonisté serotoninu metabolismus moč MeSH
- benzylaminy analýza metabolismus moč MeSH
- chromatografie na tenké vrstvě MeSH
- feces chemie MeSH
- hmotnostní spektrometrie MeSH
- inbrední kmeny potkanů MeSH
- králíci MeSH
- krysa rodu Rattus MeSH
- myši MeSH
- psi MeSH
- spektrofotometrie infračervená MeSH
- zvířata MeSH
- Check Tag
- králíci MeSH
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- myši MeSH
- psi MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antagonisté serotoninu MeSH
- benzylaminy MeSH
- VUBF 15468 MeSH Prohlížeč
Metabolites of 3-[2-(N,N-dimethylaminoethyl)phenylthio]phenol (I) were isolated from the urine of rats, mice, rabbit and dog and from the faeces of rats by extraction and thin-layer chromatography. From the mass spectrum of I and using characteristics mass shifts in the spectra of metabolites, the structures of four metabolites were determined, whereas for two other isomeric metabolites the structures were resolved by means of IR spectra. Conclusions regarding the structures derived from the spectra were confirmed by comparing them with synthetic standards. Generally, metabolic changes of I can be characterized by demethylation, hydroxylation combined with methylation, S-oxidation and by a combination of these metabolic reactions.
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