Some electrochemical characteristics of synthetic analogs of nucleic acid components. III. Derivatives of 5-fluorouridine. An attempt to find correlation between some of their characteristics
Language English Country Slovakia Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
2041581
Knihovny.cz E-resources
- MeSH
- Tegafur chemistry pharmacology MeSH
- Thioctic Acid MeSH
- Leukemia L1210 MeSH
- Tumor Cells, Cultured drug effects MeSH
- Nucleic Acids chemical synthesis MeSH
- Polarography MeSH
- Uracil Nucleotides chemistry MeSH
- Uridine analogs & derivatives chemical synthesis pharmacology MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- 5-fluorouridine MeSH Browser
- Tegafur MeSH
- Thioctic Acid MeSH
- Nucleic Acids MeSH
- Uracil Nucleotides MeSH
- Uridine MeSH
The polarographic reduction and parameter tg alpha of a series of synthetic 5-fluorouracil derivatives (various 5'-modified nucleosides) were studied. The studied compounds were compared with analogous nucleosides of the uridine series. It was confirmed that the value of tg alpha which may suggest a potential carcinogenic activity of the compound studied, is dependent upon the reducibility of the compound and is associated with the cleavability of the nucleoside bond, i.e. with the ability to liberate fluorouracil. It was found that Ftorafur, an antitumor agent widely used in clinical practice, displayed a very high value of tg alpha. In the group of polyaromates such high tg alpha values had been found in compounds which are known to have carcinogenic activity.
