UV-irradiation potentiates the antimutagenicity of p-aminobenzoic and p-aminosalicylic acids in Salmonella typhimurium
Language English Country Netherlands Media print
Document type Journal Article
PubMed
2067527
DOI
10.1016/0027-5107(91)90138-e
PII: 0027-5107(91)90138-E
Knihovny.cz E-resources
- MeSH
- Sodium Azide MeSH
- Azides toxicity MeSH
- Stimulation, Chemical MeSH
- 4-Aminobenzoic Acid pharmacology radiation effects MeSH
- Aminosalicylic Acid pharmacology radiation effects MeSH
- Methylnitronitrosoguanidine toxicity MeSH
- Methylnitrosourea metabolism MeSH
- Mutation MeSH
- Mutagens * MeSH
- Propylene Glycols toxicity MeSH
- Salmonella typhimurium genetics MeSH
- Ultraviolet Rays * MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Sodium Azide MeSH
- azidoglycerol MeSH Browser
- Azides MeSH
- 4-Aminobenzoic Acid MeSH
- Aminosalicylic Acid MeSH
- Methylnitronitrosoguanidine MeSH
- Methylnitrosourea MeSH
- Mutagens * MeSH
- Propylene Glycols MeSH
UV-irradiation (254 nm, 10 or 20 J/cm2) of p-aminobenzoic acid (PABA) and p-aminosalicylic acid (NaPAS) potentiated their antimutagenicity towards N-methyl-N'-nitro-N-nitrosoguanidine mutagenesis in Salmonella typhimurium. Their inhibitory action towards the formation of the mutagen N-methyl-N-nitrosourea from the nitrosation mixture of N-methylurea and nitrite was also increased by UV-irradiation. In contrast, UV-irradiated PABA exhibited no inhibitory effects towards the mutagenicity of sodium azide or 3-azidoglycerol. Neither PABA nor NaPAS nor their UV-irradiation products were themselves mutagenic in the Ames assay.
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