A group of 44 patients with chronic glomerulonephritis (GN) and 20 healthy subjects were investigated under the conditions of normal dietary NaCl intake and after one week of salt load with a daily addition of 5 g NaCl per os. After the salt load, the mean blood pressure increased significantly in 47% subjects (salt-sensitive) and their natriuretic response was accompanied by an increase of glomerular filtration rate. The rates of ouabain-sensitive (OST) and furosemide-sensitive transport (FST) were decreased in patients with chronic GN even before salt loading which did not change these values. The lower OST rate can be explained by a reduced affinity for internal Na+. A decreased affinity of the Na(+)-K+ cotransport system for internal Na+ was detected only in hypertensive GN patients. In our study, no relationship between salt-sensitivity and red cell sodium transport either in normotensive or in hypertensive GN patients was found.

Institute for Clinical and Experimental Medicine Prague