Blood pressure and red cell sodium transport changes following salt load in patients with glomerulonephritis
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
2142789
Knihovny.cz E-resources
- MeSH
- Biological Transport MeSH
- Adult MeSH
- Potassium pharmacology MeSH
- Erythrocytes metabolism MeSH
- Furosemide pharmacology MeSH
- Glomerulonephritis blood physiopathology MeSH
- Glomerular Filtration Rate MeSH
- Kinetics MeSH
- Blood Pressure * MeSH
- Humans MeSH
- Natriuresis MeSH
- Ouabain pharmacology MeSH
- Sodium, Dietary administration & dosage MeSH
- Sodium blood metabolism MeSH
- Body Weight MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Potassium MeSH
- Furosemide MeSH
- Ouabain MeSH
- Sodium, Dietary MeSH
- Sodium MeSH
A group of 44 patients with chronic glomerulonephritis (GN) and 20 healthy subjects were investigated under the conditions of normal dietary NaCl intake and after one week of salt load with a daily addition of 5 g NaCl per os. After the salt load, the mean blood pressure increased significantly in 47% subjects (salt-sensitive) and their natriuretic response was accompanied by an increase of glomerular filtration rate. The rates of ouabain-sensitive (OST) and furosemide-sensitive transport (FST) were decreased in patients with chronic GN even before salt loading which did not change these values. The lower OST rate can be explained by a reduced affinity for internal Na+. A decreased affinity of the Na(+)-K+ cotransport system for internal Na+ was detected only in hypertensive GN patients. In our study, no relationship between salt-sensitivity and red cell sodium transport either in normotensive or in hypertensive GN patients was found.
