Malformation spectra and embryolethality following intraamniotic administration of glucocorticoids in the chick embryo
Jazyk angličtina Země Německo Médium print
Typ dokumentu časopisecké články
PubMed
2148465
Knihovny.cz E-zdroje
- MeSH
- abnormality vyvolané léky * MeSH
- břišní svaly účinky léků embryologie MeSH
- dexamethason toxicita MeSH
- hydrokortison toxicita MeSH
- kuřecí embryo účinky léků MeSH
- morfogeneze účinky léků MeSH
- mozek účinky léků embryologie MeSH
- obličej embryologie MeSH
- oči účinky léků embryologie MeSH
- triamcinolonacetonid toxicita MeSH
- zvířata MeSH
- Check Tag
- kuřecí embryo účinky léků MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- dexamethason MeSH
- hydrokortison MeSH
- triamcinolonacetonid MeSH
The effects of a natural hormone hydrocortisone and of the synthetic corticoids dexamethasone and triamcinolone on several morphogenetic systems were investigated in 2, 3, 4 and 5 day-old chick embryos. Embryotoxic doses of the glucocorticoids were administered subgerminally on day 2, and intraamniotically on days 3, 4 and 5 of incubation. On the basis of morphological analysis of embryos performed on day 8 the malformation spectrum was determined, which shows nearly identical characteristics in all the corticoids under study. Morphogenetic systems of the body wall and face were affected most frequently; the eye only to a little extent, and the brain only rarely. No malformations of the limbs, trunk and heart were found. Embryolethal effect was observed approximately in a quarter of embryos of the individual experimental groups.
