Occurrence of some blood group antigens-like glycoconjugates in colorectal tumors
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články
PubMed
2150292
Knihovny.cz E-zdroje
- MeSH
- adenom imunologie metabolismus MeSH
- antigeny krevních skupin imunologie MeSH
- antigeny metabolismus MeSH
- glykokonjugáty metabolismus MeSH
- karcinom imunologie metabolismus MeSH
- kolorektální nádory imunologie metabolismus MeSH
- lektiny metabolismus MeSH
- lidé MeSH
- vazebná místa MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antigeny krevních skupin MeSH
- antigeny MeSH
- glykokonjugáty MeSH
- lektiny MeSH
Expression of blood antigens A1, H, and T was studied in cells of benign and malignant tumors of colon and the rectum. The aim of the experiment was to verify the hypothesis on incomplete synthesis of glycoconjugates in the course of malignancy manifested also by an enhanced expression of H antigen compared to A antigen. A total of 152 patients with blood group A1 was examined by means of lectins DBA, UEA1, and PNA. The examination was complemented by the study of other glycosylative features and CEA expression. The results obtained do not support the mentioned hypothesis but suggest that reversal to malignancy can be associated with increased glycosylation or accumulation of abnormal glycoconjugates in the cells.
