Reduction of vanadate by some psychotropic drugs (chlorpromazine, imipramine and dosulepin) and the effect of bleomycine on Na, K-ATPase
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články
PubMed
2425386
Knihovny.cz E-zdroje
- MeSH
- bleomycin farmakologie MeSH
- chlorpromazin farmakologie MeSH
- dothiepin farmakologie MeSH
- imipramin farmakologie MeSH
- mozek enzymologie MeSH
- myši MeSH
- oxidace-redukce MeSH
- psychotropní léky farmakologie MeSH
- sodíko-draslíková ATPasa metabolismus MeSH
- techniky in vitro MeSH
- vanad metabolismus MeSH
- vanadáty MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- bleomycin MeSH
- chlorpromazin MeSH
- dothiepin MeSH
- imipramin MeSH
- psychotropní léky MeSH
- sodíko-draslíková ATPasa MeSH
- vanad MeSH
- vanadáty MeSH
The reduction of vanadate (+5V) to vanadyl (+4V) was demonstrated by ESR spectra in the presence of methylene-blue, chlorpromazine, imipramine and dosulepin, but not in the presence of benzodiazepines and Li+. Bleomycine forms an (inactive) complex with +4V which may explain the disinhibition of the brain microsomal Na+-K+ ATPase in the presence of vanadyl. The reduction of +5V to +4V by antidepressants would diminish the binding of +5V to the ATPase and could account for some of the therapeutic action of the drugs in manic-depressive illness.
