Reduction of vanadate by some psychotropic drugs (chlorpromazine, imipramine and dosulepin) and the effect of bleomycine on Na, K-ATPase
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
2425386
Knihovny.cz E-resources
- MeSH
- Bleomycin pharmacology MeSH
- Chlorpromazine pharmacology MeSH
- Dothiepin pharmacology MeSH
- Imipramine pharmacology MeSH
- Brain enzymology MeSH
- Mice MeSH
- Oxidation-Reduction MeSH
- Psychotropic Drugs pharmacology MeSH
- Sodium-Potassium-Exchanging ATPase metabolism MeSH
- In Vitro Techniques MeSH
- Vanadium metabolism MeSH
- Vanadates MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Bleomycin MeSH
- Chlorpromazine MeSH
- Dothiepin MeSH
- Imipramine MeSH
- Psychotropic Drugs MeSH
- Sodium-Potassium-Exchanging ATPase MeSH
- Vanadium MeSH
- Vanadates MeSH
The reduction of vanadate (+5V) to vanadyl (+4V) was demonstrated by ESR spectra in the presence of methylene-blue, chlorpromazine, imipramine and dosulepin, but not in the presence of benzodiazepines and Li+. Bleomycine forms an (inactive) complex with +4V which may explain the disinhibition of the brain microsomal Na+-K+ ATPase in the presence of vanadyl. The reduction of +5V to +4V by antidepressants would diminish the binding of +5V to the ATPase and could account for some of the therapeutic action of the drugs in manic-depressive illness.
