Humoral immune response in experimental allergic encephalomyelitis in inbred chicken lines
Jazyk angličtina Země Česko Médium print
Typ dokumentu srovnávací studie, časopisecké články
PubMed
2449368
Knihovny.cz E-zdroje
- MeSH
- autoantigeny imunologie MeSH
- autoprotilátky biosyntéza MeSH
- encefalitogenní základní proteiny imunologie MeSH
- encefalomyelitida autoimunitní experimentální imunologie patologie MeSH
- glomerulus patologie MeSH
- imunoglobulin M biosyntéza MeSH
- inbreeding MeSH
- játra patologie MeSH
- kur domácí imunologie MeSH
- mícha imunologie MeSH
- nervový systém patologie MeSH
- slezina patologie MeSH
- zánět MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- Názvy látek
- autoantigeny MeSH
- autoprotilátky MeSH
- encefalitogenní základní proteiny MeSH
- imunoglobulin M MeSH
Chickens of the inbred IA line develop clinical signs of experimental allergic encephalomyelitis (EAE) after immunization with myelin basic protein (MP) or spinal cord tissue (SCT). The disease is accompanied by convulsions and paralysis of wings and legs. EAE leads to a 100% mortality in IA line chickens. On the other hand, no clinical signs appear in WA line and (CB x IA) F1 chickens following immunization with either antigen. The IA line and (CB x IA)F1 chickens develop severe inflammatory changes in brain and spinal cord tissues after immunization with SCT, whereas no such alterations occur in WA line chickens. Immunization with MP does not lead to histopathological changes in any chicken line investigated. MP, however, induces high production of specific IgM antibodies in all lines. IgG antibody levels are elevated only in IA line chickens after immunization with either antigen.
