The LTR, v-src, LTR provirus generated in the mammalian genome by src mRNA reverse transcription and integration
Language English Country United States Media print
Document type Journal Article
PubMed
2463374
PubMed Central
PMC247787
DOI
10.1128/jvi.63.2.1015-1018.1989
Knihovny.cz E-resources
- MeSH
- Neoplasms, Experimental microbiology MeSH
- Cricetinae MeSH
- Tumor Cells, Cultured analysis MeSH
- Oncogene Protein pp60(v-src) MeSH
- Oncogenes * MeSH
- Proviruses genetics isolation & purification MeSH
- Recombination, Genetic MeSH
- Repetitive Sequences, Nucleic Acid MeSH
- Retroviridae Proteins genetics MeSH
- RNA-Directed DNA Polymerase metabolism MeSH
- Genes, Viral * MeSH
- Viral Proteins metabolism MeSH
- Avian Sarcoma Viruses genetics isolation & purification MeSH
- Animals MeSH
- Check Tag
- Cricetinae MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Oncogene Protein pp60(v-src) MeSH
- Retroviridae Proteins MeSH
- RNA-Directed DNA Polymerase MeSH
- Viral Proteins MeSH
Different types of altered proviruses of Rous sarcoma virus (RSV) have been detected in mammalian tumor cell lines. We cloned and sequenced one of these altered proviruses with the structure LTR, v-src, LTR. The presence of an intact viral splice junction, as well as duplications of the chromosomal sequence GCGGGG flanking the two 2-base-pair-deleted LTRs, demonstrated reverse transcription and normal retroviral integration of src mRNA in mammalian cells. In addition, a 1-nucleotide deletion 2 bases upstream from the AAUAAA polyadenylation signal is suspected to be responsible for the absence of a poly(A) track in the src mRNA present in virions of rescued viruses.
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GENBANK
M21954, M21955
