Effect of N,N'-bis(alkyldimethyl)-alpha, omega-alkanediammonium dibromides on bacteria of the genus Clostridium
Language English Country United States Media print
Document type Journal Article
PubMed
2553558
DOI
10.1007/bf02821293
Knihovny.cz E-resources
- MeSH
- Benzalkonium Compounds pharmacology MeSH
- Cell Division drug effects MeSH
- Clostridium perfringens drug effects MeSH
- Clostridium drug effects MeSH
- Disinfectants pharmacology MeSH
- Quaternary Ammonium Compounds pharmacology MeSH
- Structure-Activity Relationship MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Benzalkonium Compounds MeSH
- Disinfectants MeSH
- dimethyldodecylbenzylammonium MeSH Browser
- Quaternary Ammonium Compounds MeSH
- Septonex MeSH Browser
Antibacterial effect of 17 ammonium compounds of the type of N,N'-bis(alkyldimethyl)-alpha, omega-alkanediammonium dibromides was tested on anaerobically sporulating bacteria of the genus Clostridium. A sizable antibacterial activity was displayed by five N,N'-bis(alkyldimethyl)-1,6-hexanediammonium dibromides and by four N,N'-bis(decyldimethyl)-alpha, omega-alkanediammonium dibromides. These compounds exhibited activity higher than, or comparable with, that of the reference standards Ajatin and Septonex. The maximum antibacterial activity was found in compounds whose alkyl chain contained 9-12 carbon atoms. Compounds with a lower number of carbon atoms in the chain (less than 8) exhibited a low activity.
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