The authors present a group of 20 girls and young women with various clinical symptoms of hyperandrogenism. The common finding in all these patients is an elevated excretion of desoxy-fraction of 17-oxosteroids, in particular androsterone in urine. The authors describe in detail the case-history of a girl with pubarché praecox and premature closure of the epiphyseal crevices and a young woman with polycystic ovary syndrome. The authors supplement the reflections on the aetiology of hyperandrogenism by suggestion of an algorithm examination and therapeutic procedure when excessive androgen production in the female organism is confirmed.