There is growing evidence that endocrine disruptive chemicals have deleterious effects on sexual and reproductive function. To examine subjective sexual functions in human females and their relationship to postnatal phthalate exposure and perinatal androgenization, a Sexuality Score (SS) was established from a first-stage survey questionnaire of subjective sexual function filled out by female university students (n = 68; average age 25.23 ± 5.17 years; rural 25.51 ± 6.74 vs. urban 25.85 ± 1.43 years). Seventeen phthalate metabolites in urine samples were analyzed by high-performance liquid chromatography (HPLC) and tandem mass spectrometry (MS/MS). Females were also assessed for the 2D:4D digit ratio as an index of perinatal androgenization. The mean age of menarche was 12.82 ± 1.35 years (rural 12.59 ± 1.39 vs. urban 13.18 ± 1.27; p = 0.01). The mean age at first sexual intercourse was 14.88 ± 6.89 years (rural 14.62 ± 7.20 vs. urban 15.24 ± 6.55), and as the age of first sexual intercourse increases, the SS score tends to increase as well, albeit moderately (r = 0.25, p = 0.037). Mono-iso-butyl phthalate, mono(2-ethyl-5-carboxypentyl) phthalate, mono(hydroxy-n-butyl) phthalate, mono(2-ethyl-5-oxohexyl) phthalate (p ≤ 0.05) and mono(2-carboxymethylhexyl) phthalate (p ≤ 0.01) were negatively associated with SS. A compounding butterfly effect of prenatal exposure to androgens was observed with disruptive effects of mono(2-ethyl-5-oxohexyl) phthalate and mono(2-ethyl-5-carboxypentyl) phthalate on sexual function. Exposure to phthalates in adult females may lead to disruption of subjective sexual function, especially concerning sexual desire and sexual satisfaction, and perinatal androgenization could augment these effects.
- MeSH
- Androgens * MeSH
- Adult MeSH
- Endocrine Disruptors * MeSH
- Phthalic Acids * urine MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Surveys and Questionnaires MeSH
- Sexual Behavior * drug effects MeSH
- Pregnancy MeSH
- Prenatal Exposure Delayed Effects * MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
Prostate cancer is the most common malignancy in men, mostly affecting older men who harbor an increased prevalence of cardiovascular disease and metabolic syndrome. Androgen deprivation therapy (ADT), the standard therapy for various stages of prostate cancer, further increases the risk for cardiovascular disease and for metabolic syndrome. Therefore, screening for cardiovascular risk factors should be performed prior to the initiation of ADT, and, if necessary, cardiological evaluation and interdisciplinary management should be provided during and after completion of ADT. Moreover, the use of a gonadotropin-releasing hormone (GnRH) antagonist may help reduce cardiovascular risk in patients with cardiovascular disease.
- MeSH
- Androgens MeSH
- Androgen Antagonists adverse effects MeSH
- Gonadotropin-Releasing Hormone therapeutic use MeSH
- Cardiovascular Diseases * epidemiology MeSH
- Humans MeSH
- Metabolic Syndrome * epidemiology MeSH
- Prostatic Neoplasms * drug therapy MeSH
- Aged MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Aged MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Review MeSH
- Keywords
- lanadelumab, berotralstat,
- MeSH
- Androgens administration & dosage pharmacology adverse effects therapeutic use MeSH
- Bradykinin Receptor Antagonists administration & dosage pharmacology classification therapeutic use MeSH
- Angioedemas, Hereditary * diagnosis drug therapy complications MeSH
- Antibodies, Monoclonal, Humanized pharmacology classification therapeutic use MeSH
- Quality of Life MeSH
- Humans MeSH
- Plasma Kallikrein antagonists & inhibitors administration & dosage pharmacology therapeutic use MeSH
- Premedication classification methods MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
Polycystic ovary syndrome (PCOS) and idiopathic hirsutism (IH) are androgen excess disorders requiring the determination of classic androgen levels for diagnosis. 11-oxygenated androgens have high androgenic potential, yet their clinical value in those disorders is not clear. Additionally, the role of endocrine disruptors (EDs), particularly in IH, remains understudied. We analyzed 25 steroids and 18 EDs in plasma samples from women with IH, PCOS, and controls using LC-MS/MS. Cytokine levels and metabolic parameters were assessed. Comparisons included non-obese women with PCOS (n = 10), women with IH (n = 12) and controls (n = 20), and non-obese versus obese women with PCOS (n = 9). Higher levels of 11-oxygenated androgens were observed in women with PCOS compared to those with IH, but not controls. Conversely, 11-oxygenated androgen levels were lower in women with IH compared to controls. Cytokine levels did not differ between women with IH and controls. Bisphenol A (BPA) levels were higher in obese women with PCOS compared to non-obese women with PCOS. Bisphenol S occurrence was higher in women with PCOS (90%) compared to controls (65%) and IH (50%). Significant correlations were found between androgens (11-ketotestosterone, androstenedione, testosterone) and insulin and HOMA-IR, as well as between immunomodulatory 7-oxygenated metabolites of DHEA and nine interleukins. Our data confirms that PCOS is a multiendocrine gland disorder. Higher BPA levels in obese women might exacerbate metabolic abnormalities. IH was not confirmed as an inflammatory state, and no differences in BPA levels suggest BPA does not play a role in IH pathogenesis.
- MeSH
- Androgens * blood metabolism MeSH
- Benzhydryl Compounds blood MeSH
- Cytokines blood metabolism MeSH
- Adult MeSH
- Endocrine Disruptors * blood MeSH
- Phenols MeSH
- Hirsutism * blood etiology chemically induced MeSH
- Hyperandrogenism blood MeSH
- Humans MeSH
- Young Adult MeSH
- Obesity blood metabolism MeSH
- Polycystic Ovary Syndrome * blood metabolism MeSH
- Tandem Mass Spectrometry MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Young Adult MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- MeSH
- Androgens therapeutic use MeSH
- Biomedical Research MeSH
- Fecal Microbiota Transplantation MeSH
- Liver Cirrhosis complications pathology MeSH
- Hepatic Encephalopathy etiology therapy MeSH
- Clinical Studies as Topic MeSH
- Humans MeSH
- Liver Diseases * diagnosis drug therapy prevention & control therapy MeSH
- Organizations MeSH
- Protein Glutamine gamma Glutamyltransferase 2 antagonists & inhibitors MeSH
- Liver Failure therapy MeSH
- Liver Transplantation MeSH
- Fatty Liver drug therapy MeSH
- Check Tag
- Humans MeSH
- Publication type
- Newspaper Article MeSH
Androgenetická alopecie je progresivní, hereditární, nejizvící, androgen-dependentní ztráta vlasů. Patří k nejčastějším onemocněním vlasů. Komplexní přístup k problematice androgenetické alopecie zaručuje optimální léčebnou odpověď s příznivým ovlivněním kvality života pacientů s androgeneticku alopecií.
Androgenetic alopecia is a type of progressive, hereditary, non-scaring, androgen-dependent hair loss. It ranks among the most common hair-affecting conditions in general. A complex approach to the issue of androgenetic alopecia guarantees optimal therapeutic response with a positive influence on the quality of life of patients with androgenetic alopecia.
- Keywords
- paruky,
- MeSH
- Alopecia * diagnosis physiopathology pathology therapy MeSH
- Androgens biosynthesis physiology metabolism MeSH
- Dermatologic Agents administration & dosage pharmacology classification MeSH
- Dutasteride administration & dosage pharmacology adverse effects MeSH
- Finasteride administration & dosage pharmacology adverse effects MeSH
- Hormone Replacement Therapy methods MeSH
- 5-alpha Reductase Inhibitors administration & dosage pharmacology classification adverse effects MeSH
- Humans MeSH
- Minoxidil administration & dosage pharmacology classification MeSH
- Prostheses and Implants MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
Information on the indoor environment as a source of exposure with potential adverse health effects is mostly limited to a few pollutant groups and indoor types. This study provides a comprehensive toxicological profile of chemical mixtures associated with dust from various types of indoor environments, namely cars, houses, prefabricated apartments, kindergartens, offices, public spaces, and schools. Organic extracts of two different polarities and bioaccessible extracts mimicking the gastrointestinal conditions were prepared from two different particle size fractions of dust. These extracts were tested on a battery of human cell-based bioassays to assess endocrine disrupting potentials. Furthermore, 155 chemicals from different pollutant groups were measured and their relevance for the bioactivity was determined using concentration addition modelling. The exhaustive and bioaccessible extracts of dust from the different microenvironments interfered with aryl hydrocarbon receptor, estrogen, androgen, glucocorticoid, and thyroid hormone (TH) receptor signalling, and with TH transport. Noteably, bioaccessible extracts from offices and public spaces showed higher estrogenic effects than the organic solvent extracts. 114 of the 155 targeted chemicals were detectable, but the observed bioactivity could be only marginally explained by the detected chemicals. Diverse toxicity patterns across different microenvironments that people inhabit throughout their lifetime indicate potential health and developmental risks, especially for children. Limited data on the endocrine disrupting potency of relevant chemical classes, especially those deployed as replacements for legacy contaminants, requires further study.
X-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association meta-analysis of seven kidney-related traits (n = 908,697), identifying 23 loci genome-wide significantly associated with two of the traits: 7 for uric acid and 16 for estimated glomerular filtration rate (eGFR), including four novel eGFR loci containing the functionally plausible prioritized genes ACSL4, CLDN2, TSPAN6 and the female-specific DRP2. Further, we identified five novel sex-interactions, comprising male-specific effects at FAM9B and AR/EDA2R, and three sex-differential findings with larger genetic effect sizes in males at DCAF12L1 and MST4 and larger effect sizes in females at HPRT1. All prioritized genes in loci showing significant sex-interactions were located next to androgen response elements (ARE). Five ARE genes showed sex-differential expressions. This study contributes new insights into sex-dimorphisms of kidney traits along with new prioritized gene targets for further molecular research.
- MeSH
- Androgens * genetics MeSH
- Genome-Wide Association Study * MeSH
- Genetic Predisposition to Disease MeSH
- Polymorphism, Single Nucleotide MeSH
- Kidney MeSH
- Humans MeSH
- Chromosomes, Human, X genetics MeSH
- Response Elements MeSH
- Tetraspanins genetics MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Meta-Analysis MeSH
Autor v článku podává informaci o diagnostice mužského hypogonadismu a léčbě testosteronem, včetně nejnovějších doporučení k léčbě a sledování pacientů podle Evropské urologické společnosti (EAU).
The author provides information about the diagnostics of male hypogonadism and testosterone replacement therapy - including the latest recommendations for the patients treatment and monitoring according to the European Association of Urology (EAU).
- MeSH
- Androgens blood MeSH
- Hypogonadism * diagnosis drug therapy classification MeSH
- Humans MeSH
- Testosterone administration & dosage therapeutic use MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Publication type
- Review MeSH
- MeSH
- Androgens metabolism MeSH
- Estrogens metabolism MeSH
- Granulosa Cells MeSH
- Follicle Stimulating Hormone MeSH
- Gonadotropin-Releasing Hormone MeSH
- Humans MeSH
- Luteinizing Hormone MeSH
- Ovary physiology MeSH
- Gonadal Steroid Hormones * MeSH
- Progestins metabolism MeSH
- Theca Cells MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
