Demonstration of proteinase inhibitors cystatin A, B and C in breast cancer and in cell lines MCF-7 and ZR-75-1
Jazyk angličtina Země Slovensko Médium print
Typ dokumentu časopisecké články
PubMed
2785657
Knihovny.cz E-zdroje
- MeSH
- buněčné linie MeSH
- cystatin B MeSH
- cystatin C MeSH
- cystatiny * MeSH
- estradiol farmakologie MeSH
- inhibitory cysteinových proteinas * MeSH
- inhibitory proteas analýza biosyntéza MeSH
- lidé MeSH
- nádorové buňky kultivované analýza MeSH
- nádory prsu analýza metabolismus MeSH
- proteiny analýza MeSH
- proteosyntéza MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- CST3 protein, human MeSH Prohlížeč
- CSTB protein, human MeSH Prohlížeč
- cystatin B MeSH
- cystatin C MeSH
- cystatiny * MeSH
- estradiol MeSH
- inhibitory cysteinových proteinas * MeSH
- inhibitory proteas MeSH
- proteiny MeSH
Polyclonal rabbit antibodies to endogenous natural inhibitors of cysteine proteinases (cystatins) were used for their immunohistochemical demonstration in samples of breast cancers and in two breast cancer derived cell lines (MCF-7 and ZR-75-1). The influence of estrogen stimulation on the expression of these inhibitors was also studied. The results showed that all cystatins tested can be found equally inside carcinomatous cells or in surrounding connective tissue, as well as in both cell lines examined. Further, the expression of inhibitors can be regulated by estrogen, and a certain role of cystatins in the regulation of the mitotic activity and differentiation of mammary cells can be supposed.
