Arachidonate activates muscle electrogenic sodium pump and brain microsome Na+,K+-ATPase under suboptimal conditions
Language English Country Netherlands Media print
Document type Journal Article
PubMed
2825927
DOI
10.1016/0006-8993(87)91559-9
PII: 0006-8993(87)91559-9
Knihovny.cz E-resources
- MeSH
- Diaphragm drug effects metabolism physiology MeSH
- Potassium metabolism MeSH
- Electrophysiology MeSH
- Arachidonic Acids pharmacology MeSH
- Microsomes drug effects enzymology MeSH
- Brain drug effects enzymology MeSH
- Mice MeSH
- Sodium metabolism MeSH
- Sodium-Potassium-Exchanging ATPase metabolism MeSH
- Muscles drug effects metabolism physiology MeSH
- In Vitro Techniques MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Potassium MeSH
- Arachidonic Acids MeSH
- Sodium MeSH
- Sodium-Potassium-Exchanging ATPase MeSH
Arachidonate 5 x 10(-5) mol.l-1 increased the rate of hyperpolarization induced in Na+-loaded mouse diaphragm fibers by 5 mmol.l-1 K+. When applied to Na+-loaded muscles without potassium, arachidonate 1 x 10(-6) and 5 x 10(-5) mol.l-1 induced a ouabain-sensitive hyperpolarization of the muscle fibers. The activity of rat brain microsomal Na+,K+-ATPase was stimulated by 1 x 10(-7)-5 x 10(-6) mol.l-1 arachidonate in reaction media with reduced amounts of ATP or K+ and after short-lasting sonication of the samples. It was concluded that, under particular conditions, arachidonate might serve as a Na+,K+-ATPase activator or inhibitor regulating its ion transport and electrogenicity.
References provided by Crossref.org
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