Effect of indomethacin on the proliferative and differentiation activity in the haemopoietic system of lethally irradiated mice after syngeneic bone marrow transplantation
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
2893752
Knihovny.cz E-resources
- MeSH
- Cell Differentiation drug effects MeSH
- Cell Division drug effects MeSH
- Hematopoietic Stem Cells cytology drug effects MeSH
- Hematopoiesis drug effects MeSH
- Indomethacin pharmacology MeSH
- Mice, Inbred C57BL MeSH
- Mice, Inbred CBA MeSH
- Mice MeSH
- Prostaglandins physiology MeSH
- Radiation Chimera MeSH
- Spleen cytology MeSH
- Hematopoietic Stem Cell Transplantation MeSH
- Bone Marrow Transplantation * MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Indomethacin MeSH
- Prostaglandins MeSH
The effects of indomethacin treatment on the proliferation and differentiation of haemopoietic stem cells of bone marrow grafts in lethally irradiated mice were investigated. Indomethacin was given subcutaneously, on days 3 to 5 after irradiation, in 6 doses of 0.05 mg per mouse. On day 6 after irradiation, an increased self-renewal of the settled colony-forming cells and an increased amount of differentiated cells were observed in the spleens of the mice treated. Simultaneously, a decreased maturation of the erythroid cells was demonstrated. The effects observed may be explained by the indomethacin-induced inhibition of prostaglandin biosynthesis.
Stimulatory action of cyclooxygenase inhibitors on hematopoiesis: a review
