Embryotoxicity of L-prolyl-L-leucyl-glycinamide, cyclo(1-amino-cyclopentanecarbonyl-alanyl) and cyclo(glycyl-leucyl), new potential neuropeptides in chick embryos
Language English Country Germany Media print
Document type Journal Article
PubMed
2905482
Knihovny.cz E-resources
- MeSH
- Abnormalities, Drug-Induced * MeSH
- Peptides, Cyclic toxicity MeSH
- MSH Release-Inhibiting Hormone toxicity MeSH
- Chick Embryo MeSH
- Neuropeptides toxicity MeSH
- Animals MeSH
- Check Tag
- Chick Embryo MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- cyclo(alanine-(1-amino-1-cyclopentane)carbonyl) MeSH Browser
- cyclo(leucylglycine) MeSH Browser
- Peptides, Cyclic MeSH
- MSH Release-Inhibiting Hormone MeSH
- Neuropeptides MeSH
With the use of the method Chick Embryotoxicity Screening Test II (CHEST II), the potential neuropeptides L-prolyl-L-leucyl-glycinamide (MIF), cyclo(1-aminocyclo-pentanecarbonyl-L-alanyl)[cyclo(Acp-Ala)] and cyclo(glycyl-L-leucyl)[Cyclo(Gly-Leu)] were tested in the critical developmental periods of d 1.5 to 4 of chick embryogenesis in order to objectively examine their undesirable interactions with the developing morphogenetic systems of the brain, eye, face, body wall, limbs, trunk and heart. All compounds tested showed positive dose- and stage-response relationships. The body wall defects are the prevailing type of malformations.
In vitro permeation of micronized and nanonized alaptide from semisolid formulations
