A collection of 20 compounds was tested for their ability to induce a permanent loss of chloroplasts from Euglena gracilis cells under conditions increasing the sensitivity of the flagellate to genotoxic compounds, viz. in the resting medium and at an elevated temperature. Streptomycin, dihydrostreptomycin, gentamicin, kanamycin and partially chloramphenicol exhibited mutagenic effects. Eight antibiotics eliminated chloroplasts only from growing cultures and seven antibiotics did not induce the mutation at all.

Institute of Molecular and Subcellular Biology Comenius University Bratislava Czechoslovakia

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Euglena gracilis as a supplementary test organism for detecting biologically active compounds