Effects of bilirubin on murine peritoneal and spleen cells
Jazyk angličtina Země Dánsko Médium print
Typ dokumentu časopisecké články
PubMed
3261984
Knihovny.cz E-zdroje
- MeSH
- antigeny povrchové imunologie MeSH
- B-lymfocyty účinky léků imunologie MeSH
- bilirubin farmakokinetika farmakologie MeSH
- makrofágy účinky léků imunologie MeSH
- myši inbrední BALB C MeSH
- myši MeSH
- peritoneum cytologie účinky léků imunologie MeSH
- receptory Fc účinky léků imunologie MeSH
- slezina cytologie účinky léků imunologie MeSH
- T-lymfocyty účinky léků imunologie MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antigeny povrchové MeSH
- bilirubin MeSH
- receptory Fc MeSH
The effect of bilirubin on murine peritoneal and spleen cells was investigated. Bilirubin was found to have a strong and rapid effect on the expression of various kinds of Fc receptors on peritoneal macrophages. Significant changes were observed 30 min after the infection of bilirubin. The return to normal values was not observed earlier than after 24 h. The effect of bilirubin on Fc receptor expression of splenic macrophages was less pronounced. Expression of Ia antigen on macrophages was not influenced by bilirubin. The changes in percentage of sIg+ and Thy 1.2+ lymphocytes reflect a change in the ratio of T to B cells in the peritoneal cavity, as bilirubin caused 40% increase in numbers of B cells and a similar decrease in numbers of T cells. The percentage of splenic B lymphocytes was not influenced by bilirubin injection; but the ratio of T helper to suppressor cells was altered.
The stimulatory effect of bilirubin on phagocytic activity
