Effects of bilirubin on murine peritoneal and spleen cells
Language English Country Denmark Media print
Document type Journal Article
PubMed
3261984
Knihovny.cz E-resources
- MeSH
- Antigens, Surface immunology MeSH
- B-Lymphocytes drug effects immunology MeSH
- Bilirubin pharmacokinetics pharmacology MeSH
- Macrophages drug effects immunology MeSH
- Mice, Inbred BALB C MeSH
- Mice MeSH
- Peritoneum cytology drug effects immunology MeSH
- Receptors, Fc drug effects immunology MeSH
- Spleen cytology drug effects immunology MeSH
- T-Lymphocytes drug effects immunology MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Antigens, Surface MeSH
- Bilirubin MeSH
- Receptors, Fc MeSH
The effect of bilirubin on murine peritoneal and spleen cells was investigated. Bilirubin was found to have a strong and rapid effect on the expression of various kinds of Fc receptors on peritoneal macrophages. Significant changes were observed 30 min after the infection of bilirubin. The return to normal values was not observed earlier than after 24 h. The effect of bilirubin on Fc receptor expression of splenic macrophages was less pronounced. Expression of Ia antigen on macrophages was not influenced by bilirubin. The changes in percentage of sIg+ and Thy 1.2+ lymphocytes reflect a change in the ratio of T to B cells in the peritoneal cavity, as bilirubin caused 40% increase in numbers of B cells and a similar decrease in numbers of T cells. The percentage of splenic B lymphocytes was not influenced by bilirubin injection; but the ratio of T helper to suppressor cells was altered.
The stimulatory effect of bilirubin on phagocytic activity
