Does status epilepticus induced at early postnatal period change excitability after cortical epileptic afterdischarges?
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
27346862
DOI
10.1111/epi.13438
Knihovny.cz E-resources
- Keywords
- Cortical stimulation, Epileptic afterdischarges, Ontogeny, Rat, Status epilepticus,
- MeSH
- Electric Stimulation adverse effects MeSH
- Electroencephalography MeSH
- Rats MeSH
- Disease Models, Animal MeSH
- Cerebral Cortex physiopathology MeSH
- Animals, Newborn MeSH
- Rats, Wistar MeSH
- Status Epilepticus etiology pathology MeSH
- Age Factors MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Possible changes of cortical excitability after status epilepticus (SE) elicited in 12-day-old rats were studied by means of paired cortical afterdischarges (ADs). Consequences of lithium-pilocarpine status were studied in animals with implanted electrodes 3, 6, 9, 13, and 26 days after SE. Paired low-frequency stimulation with a 1-min interval was repeated after 10 min, and duration of ADs was measured. Control rats received saline instead of pilocarpine; other treatments were the same as in SE group. Postictal refractoriness (i.e., the testing response significantly shorter than the conditioning one) appeared at the age of 18 days in lithium-paraldehyde controls, whereas SE animals exhibited this phenomenon since postnatal day 21. The only significant difference between SE and lithium-paraldehyde controls was found in the second conditioning AD in the oldest group studied-it was longer in 38-day-old SE animals. Our results demonstrated moderate signs of higher excitability of SE rats in comparison with control ones long before appearance of spontaneous seizures.
References provided by Crossref.org
Epilepsy Research in the Institute of Physiology of the Czech Academy of Sciences in Prague
