Analysis of epidermal growth factor and epidermal growth factor receptor expression in human renal carcinoma cell cultures
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
3266485
Knihovny.cz E-resources
- MeSH
- Cell Division MeSH
- Cell Line MeSH
- Epidermal Growth Factor biosynthesis pharmacology MeSH
- ErbB Receptors biosynthesis drug effects metabolism MeSH
- Carcinoma, Renal Cell metabolism MeSH
- Kinetics MeSH
- Humans MeSH
- Kidney Neoplasms metabolism MeSH
- Suramin pharmacology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Epidermal Growth Factor MeSH
- ErbB Receptors MeSH
- Suramin MeSH
In cells derived from two human renal carcinomas only the precursor form of epidermal growth factor (EGF) was found. The binding assay revealed a high level of EGF receptor expression in both cell types tested. However, these receptors are not involved in the growth activity of the cells under in vitro conditions used. The source of DNA synthesis-stimulating activity found in conditioned media of the cells tested is discussed with respect to possible participation of TGF beta.
